Association study of TRAF1/C5 polymorphism (rs10818488) with susceptibility to rheumatoid arthritis and systemic lupus erythematosus: A meta-analysis
Association study of TRAF1/C5 polymorphism (rs10818488) with susceptibility to rheumatoid arthritis and systemic lupus erythematosus: A meta-analysis
复制标题
DOI：
10.1016/j.gene.2012.12.092
复制
发表时间：
2013-03-15
期刊：
影响因子：
3.5
通讯作者：
Ye, Dong-Qing
中科院分区：
文献类型：
--
作者：
Xu, Ke;Peng, Hui;Ye, Dong-Qing
为确定肿瘤坏死因子受体相关因子1/补体成分5(TRAF1/C5)基因多态性(Rs10818488)是否与类风湿性关节炎(RA)和系统性红斑狼疮(SLE)易感性有关，进行了Meta分析。共有11项研究和17项对照(11项为类风湿性关节炎，6项为系统性红斑狼疮)可用于荟萃分析，其中包括13,456名类风湿关节炎患者，12,259名对照和1,894名对照，6,729名系统性红斑狼疮对照。在北非人群中发现TRAF1/C5基因A等位基因(Rs10818488)与RA易感性显著相关(OR=1557，95%CI：1.225~1.977)。此外，在欧洲人群中还发现该等位基因变异与系统性红斑狼疮风险的关联(OR=1.247，95%CI：1.060~1.466)。TRAF1/C5变异株(Rs10818488)A/G等位基因频率在不同健康人群中的分布也不同(x~(2)=269.41，P
To determine whether the tumor necrosis factor (TNF)-receptor associated factor 1/complement component 5 (TRAF1/C5) polymorphism (rs10818488) confers susceptibility to rheumatoid arthritis (RA) and systemic lupus erythematous (SLE), a meta-analysis was performed. A total of 11 studies with 17 comparisons (11 for RA, 6 for SLE) were available for this meta-analysis, which consisted of 13,456 patients, 12,259 controls for RA and 1,894 patients, 6,729 controls for SLE. A significant association of the A allele of TRAF1/C5 polymorphism (rs10818488) with RA susceptibility was detected in the North Africa population (OR = 1557, 95% Cl: 1.225-1.977). Furthermore, the association between this allelic variant and SLE risk was additionally found in population of European (OR = 1.247, 95% Cl: 1.060-1.466). Analysis also showed the A/G allelic frequency of TRAF1/C5 variant (rs10818488), in different healthy populations, had a different distribution (chi(2) = 269.41, P