New insights on the reparative cells in bone regeneration and repair
New insights on the reparative cells in bone regeneration and repair
复制标题
关于修复细胞在骨再生和修复中的新见解。
DOI：
10.1111/brv.12659
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发表时间：
2020-10-13
影响因子：
10
通讯作者：
Chen, Lin
中科院分区：
文献类型：
--
作者：
Huang, Shuo;Jin, Min;Chen, Lin
骨具有显著的修复能力，可完全再生而不形成瘢痕组织。这种独特的特征在骨发育、维持和损伤（骨折）愈合期间表达，由包括骨骼干细胞（SSC）及其后代的修复细胞执行。然而，由于技术上的困难以及精原干细胞的异质性和可塑性，精原干细胞的身份和功能仍然存在争议。而且，多年来一直有一种偏见，认为骨髓是骨修复的主要细胞来源。总之，这些限制极大地阻碍了我们对这些重要细胞群及其在骨折和骨骼疾病治疗中的潜在应用的理解。在这里，我们重新分析和总结了目前对骨再生和修复中修复细胞的理解，并概述了这一领域的最新进展，特别强调了骨折愈合的时间和空间过程，修复细胞的来源，SSC的最新定义，以及有助于颅面和长骨修复的骨骼干/祖细胞标志物，以及精原干细胞和周细胞之间的争论。最后，我们还讨论了该领域存在的问题，新兴的新技术和未来的研究方向。
Bone possesses a remarkable repair capacity to regenerate completely without scar tissue formation. This unique characteristic, expressed during bone development, maintenance and injury (fracture) healing, is performed by the reparative cells including skeletal stem cells (SSCs) and their descendants. However, the identity and functional roles of SSCs remain controversial due to technological difficulties and the heterogeneity and plasticity of SSCs. Moreover, for many years, there has been a biased view that bone marrow is the main cell source for bone repair. Together, these limitations have greatly hampered our understanding of these important cell populations and their potential applications in the treatment of fractures and skeletal diseases. Here, we reanalyse and summarize current understanding of the reparative cells in bone regeneration and repair and outline recent progress in this area, with a particular emphasis on the temporal and spatial process of fracture healing, the sources of reparative cells, an updated definition of SSCs, and markers of skeletal stem/progenitor cells contributing to the repair of craniofacial and long bones, as well as the debate between SSCs and pericytes. Finally, we also discuss the existing problems, emerging novel technologies and future research directions in this field.