Fetal alcohol syndrome: neuropsychiatric phenomics
Fetal alcohol syndrome: neuropsychiatric phenomics
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DOI：
10.1016/j.ntt.2003.07.014
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发表时间：
2003-11-01
影响因子：
2.9
通讯作者：
Kerbeshian, J
中科院分区：
文献类型：
--
作者：
Burd, L;Klug, MG;Kerbeshian, J
胎儿酒精综合征（FAS）是一种常见的发育障碍，在多个神经精神领域有不同程度的损害。关于行为表型的群体衍生研究很少。本研究的目的是估计三组中神经精神疾病的患病率：符合FAS标准的受试者（n = 152）；符合部分FAS/ARND标准的受试者（n = 150）；并纳入不符合FAS或部分FAS/ARND标准的受试者（n = 86）。每位受试者都由医学遗传学家进行了标准化评估。所有受试者均来自北达科他州。我们发现，与部分FAS/ARND患者相比，FAS患者的神经精神疾病患病率增加，而在不符合FAS或部分FAS/ARND标准的组中，患病率最低。73%的FAS患者、72%的部分FAS/ARND患者和36%的不符合这两种标准的受试者出现了共病性注意缺陷多动障碍。对于其他神经精神疾病，也发现了类似的合并症分布。这项研究支持了产前酒精暴露导致连续损伤的概念。在产前酒精暴露的受影响受试者中存在复杂的认知，行为和身体症状似乎很适合胎儿酒精谱系障碍（FASD）的诊断标题。诊断和长期管理将需要更多地利用多学科儿童发展小组，包括治疗儿童和青少年的心理健康专业人员。成年人将需要主要由具有心理健康和发育障碍专业知识的小组提供护理。(C) 2003 Elsevier Inc.版权所有。
Fetal alcohol syndrome (FAS) is a common developmental disorder with impairments in multiple neuropsychiatric spheres of varying severity. Few population-derived studies of the behavioral phenotype are available.The purpose of this study was to estimate the prevalence of neuropsychiatric disorders in three groups: subjects who met criteria for FAS (n = 152); subjects who met criteria for partial FAS/ARND (n = 150); and referred subjects who did not meet criteria for either FAS or partial FAS/ARND (n = 86). Each subject had a standardized evaluation by a medical geneticist. All subjects were from North Dakota.We found increases in the prevalence rates of neuropsychiatric disorders in subjects with FAS compared to subjects with partial FAS/ARND and the lowest rates in the group that did not meet criteria for either FAS or partial FAS/ARND. Comorbid attention deficit hyperactivity disorder occurred in 73% of cases with FAS, in 72% cases with partial FAS/ARND, and in 36% subjects who did not meet criteria for either. For other neuropsychiatric disorders, a similar distribution of comorbidity was found. This study supports the concept of a continuum of impairment resulting from prenatal alcohol exposure.The presence of complex cognitive, behavioral, and physical symptomatology in the affected subjects with prenatal alcohol exposure would seem to fit well under the diagnostic rubric of fetal alcohol spectrum disorder (FASD). Diagnosis and long-term management will require increasing access to multidisciplinary child development teams including mental health professionals who treat children and adolescents. Adults will require care primarily from teams with expertise in mental health and developmental disabilities. (C) 2003 Elsevier Inc. All rights reserved.