Airway and metabolic resistance to intravenous salbutamol: a study in normal man.
Airway and metabolic resistance to intravenous salbutamol: a study in normal man.
复制标题
对静脉注射沙丁胺醇的气道和代谢抵抗：对正常人的一项研究。
作者：
S. Holgate;W. Stubbs;P. Wood;E. McCaughey;K. Alberti;A. Tattersfield
1.在正常受试者中研究了长期吸入沙丁胺醇（每天1600 μ g，持续2周）前后对静脉注射β 2-激动剂沙丁胺醇的气道和代谢反应。2.在慢性吸入沙丁胺醇之前，累积剂量为25至300微克的沙丁胺醇静脉给药后，比气道传导率呈剂量依赖性增加。3.在每次增加沙丁胺醇后测量血糖、乳酸盐、丙酮酸盐、甘油、酮体、非酯化脂肪酸、胰岛素、血浆环AMP和环GMP的浓度，除环GMP外，所有浓度均显示增加。4.慢性吸入沙丁胺醇后，气道、代谢和胰岛素对静脉注射沙丁胺醇的反应降低。cAMP反应变化不大。5.本研究证实了正常受试者吸入大剂量沙丁胺醇后气道中肾上腺素能抵抗的发展，并表明这与广泛的代谢性肾上腺素能抵抗有关。
1. The airway and metabolic responses to an intravenous beta 2-agonist salbutamol have been investigated in normal subjects before and after chronic administration of inhaled salbutamol, 1600 micrograms daily for 2 weeks. 2. Before chronic inhalation of salbutamol there was a dose-dependent increase in specific airway conductance after intravenous salbutamol in cumulative doses from 25 to 300 micrograms. 3. Measurement of concentrations of blood glucose, lactate, pyruvate, glycerol, ketone bodies, non-esterified fatty acids, insulin, plasma cyclic AMP and cyclic GMP were made after each increment of salbutamol and all showed an increase apart from cyclic GMP. 4. After chronic inhalation of salbutamol there was a decrease in the airway, metabolic and insulin response to intravenous salbutamol. The cyclic AMP response showed little change. 5. This study confirms the development of adrenergic resistance in the airways of normal subjects after large does of inhaled salbutamol and shows that this is associated with widespread metabolic adrenergic resistance.