Ontogeny of blood-brain barrier function in ovine fetuses, lambs, and adults.
Ontogeny of blood-brain barrier function in ovine fetuses, lambs, and adults.
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绵羊胎儿、羔羊和成年血脑屏障功能的个体发育。
DOI：
10.1152/ajpregu.1996.271.6.r1594
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Cserr,HF
中科院分区：
文献类型：
--
作者：
Stonestreet,BS;Patlak,CS;Pettigrew,KD;Reilly,CB;Cserr,HF
用小分子合成惰性亲水性氨基酸α-氨基异丁酸(AIB)对妊娠早期(妊娠87天，妊娠60%)和妊娠晚期(妊娠137天，妊娠90%)的绵羊、新生儿(3日龄)、老年人(24日龄)和成年(3日龄)绵羊的血脑屏障功能的个体发育进行了定量。与妊娠60%和90%的胎儿相比，成年绵羊的大脑区域和新生羔羊和成年羔羊的大部分大脑区域的Ki显著降低(P<；0.05)。KI在五组中表现出区域脑异质性(P<；0.05)。在较年轻的人群中，区域异质性的模式更加明显(P<；0.05)。我们得出结论，从妊娠60%到成年，绵羊胎儿血脑屏障通透性的个体源性降低。
The ontogeny of regional blood-brain barrier function was quantified with the rate constant for influx (Ki) across the blood-brain barrier with the small molecular weight synthetic, inert hydrophilic amino acid alpha-aminoisobutyric acid (AIB) in chronically instrumented early (87 days of gestation, 60% of gestation) and late (137 days of gestation, 90% of gestation) gestation fetal, newborn (3 days of age), older (24 days of age), and adult (3 years of age) sheep. The Ki was significantly (P < 0.05) lower in the brain regions of the adult sheep and in most brain regions of newborn and older lambs compared with fetuses at 60 and 90% of gestation. The Ki exhibited regional brain heterogeneity (P < 0.05) in the five groups. The patterns of regional heterogeneity were accentuated (P < 0.05) in the younger groups. We conclude that ontogenic decreases in blood-brain barrier permeability are observed in ovine fetuses from 60% of gestation to maturity in the adult.