Disturbed intracortical excitability in early Parkinson's disease is L-DOPA dose related: A prospective 12-month paired TMS study
Disturbed intracortical excitability in early Parkinson's disease is L-DOPA dose related: A prospective 12-month paired TMS study
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DOI：
10.1016/j.parkreldis.2007.02.008
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发表时间：
2007-01-01
影响因子：
4.1
通讯作者：
Rektor, Ivan
中科院分区：
文献类型：
--
作者：
Bares, Martin;Kanovsky, Petr;Rektor, Ivan
我们有兴趣知道长期左旋多巴治疗帕金森病（PD）患者是否可以恢复皮质内兴奋性的损害，何时可能出现这种差异，以及它是否与左旋多巴的每日总剂量有关。12例早期PD患者在服用左旋多巴前、服用左旋多巴3个月、6个月和12个月后进行配对经颅磁刺激研究。皮质内兴奋性紊乱的程度与左旋多巴的每日总剂量密切相关。PD患者的皮质兴奋性水平似乎与黑质-纹状体功能间接相关。(c)2007爱思唯尔有限公司保留所有权利。
We were interested to know if chronic L-DOPA treatment in Parkinson's disease (PD) patients could restore impairment of the intracortical excitability, when this difference could occur, and if it was related to the total daily dose Of L-DOPA. Twelve patients with early PD were studied using paired transcranial magnetic stimulation before the administration Of L-DOPA, and then after 3, 6, and 12 months Of L-DOPA treatment. The level of disturbed intracortical excitability strongly correlated with the total daily dose Of L-DOPA. The level of cortical excitability in PD patients seems to be indirectly related to the nigro-striatal functioning. (c) 2007 Elsevier Ltd. All rights reserved.