Supramolecular self-assembly of a hybrid 'hyalurosome' for targeted photothermal therapy in non-small cell lung cancer
Supramolecular self-assembly of a hybrid 'hyalurosome' for targeted photothermal therapy in non-small cell lung cancer
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用于非小细胞肺癌靶向光热治疗的混合“透明质体”的超分子自组装
DOI：
10.1080/10717544.2020.1730521
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发表时间：
2020
期刊：
影响因子：
6
通讯作者：
Wang Changli
中科院分区：
文献类型：
--
作者：
Xu Haipeng;Dong Lin;Bin Zhang;Huo Yansong;Lin Shaofeng;Chang Liu;Chen Chen;Wang Changli
尽管光反应疗法在非小细胞肺癌（NSCLC）的治疗中具有良好的疗效和低毒性，但其细胞通透性和体内不稳定性限制了吲哚菁类光敏剂的进一步临床应用。在这里，我们探讨的超分子自组装的“透明体”，是由磷酸钙纳米核介导的。通过透明质酸介导的CD44靶向，构建的透明质体特异性地将ICG递送到NSCLC细胞中，然后诱导严重的高热，伴随着光照射时单线态氧的产生。与天然形式的作用相反，包裹在透明体中的吲哚菁绿色在体外和体内均显示出显著增加的细胞内吞作用和抑制细胞增殖。我们的研究表明，这种透明体是一个有前途的候选人的靶向输送光敏剂，这可能是有用的非小细胞肺癌治疗。
Despite the excellent efficacy and low toxicity of photoresponse therapy, which has attracted considerable attention for use in non-small cell lung cancer (NSCLC) therapy, unsatisfactory cellular permeability, and instability, bothin vitroandin vivohave limited further clinical applications of indole cyanine photosensitizers. Here, we explore the supramolecular self-assembly of a ‘hyalurosome’ that is mediated by calcium phosphate nanonuclei. Through hyaluronate-mediated CD44 targeting, the constructed hyalurosome specifically delivers ICG into NSCLC cells and then induces severe hyperthermia accompanied by the generation of singlet oxygen upon photoirradiation. In contrast to the action of the native form, indocyanine green encapsulated in a hyalurosome showed significantly increased cellular endocytosis and inhibited cell proliferation bothin vitroandin vivo. Our study indicated that this hyalurosome is a promising candidate for the targeted delivery of photosensitizers, which may be useful in NSCLC therapy.