Depressive symptomatology is influenced by chronotypes
Depressive symptomatology is influenced by chronotypes
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DOI：
10.1016/j.jad.2009.02.021
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发表时间：
2009-12-01
影响因子：
6.6
通讯作者：
Serretti, Alessandro
中科院分区：
文献类型：
--
作者：
Gaspar-Barba, Enrique;Calati, Raffaella;Serretti, Alessandro
背景：节律紊乱是抑郁症常见的临床表现。近年来，抑郁症和生理时钟类型之间的可能关系已经出现。具体而言，已提出晚上作为脆弱性因素。本研究的目的是描述抑郁症患者的睡眠功能，根据时间类型，并探讨可能的协会与抑郁epissions.Methods的临床特征：100例诊断为重度抑郁症根据迷你国际神经精神访谈（MINI）（年龄：34 +/- 11.74，范围：18-60岁;女性/男性：79/21）。入院时，采用汉密尔顿抑郁量表（HRSD）。结果：根据MEQ评分将患者分为3组：a）夜间型（n = 18），B）非夜间型（n = 61）和c）晨起型（n = 21）。年龄是不同的时钟类型，早晨型患者年龄较大。夜间型组自杀意念、工作和活动受损、偏执症状、焦虑症状（HRSD）得分较高，晨起型组抑郁症状（MINI）比例较低。我们没有发现睡眠参数和特定的chronotypes.Limitations之间的关联：相对较小的样本量和同步评估的chronotypes和抑郁症可能有偏见，我们的findings.Conclusions：我们的数据表明的想法，chronotypes有抑郁发作功能的影响，具有较高的严重程度的evenness-type。(C)2009爱思唯尔有限公司版权所有。
Background: Rhythm disturbances are a frequent clinical manifestation of depression. In recent years a possible relationship between depression and chronotypes has emerged. Specifically eveningness has been proposed as vulnerability factor. The aim of this study was to describe sleep features of depressed patients according to chronotypes and to explore possible associations with the clinical features of depressive episodes.Methods: 100 patients diagnosed with Major Depressive Disorder according to the Mini International Neuropsychiatric Interview (MINI) were included (age: 34 +/- 11.74, range: 18-60 years; female/male:79/21). At admission the Hamilton Rating Scale for Depression (HRSD) was administered. Patients were also administered the Morningness-Eveningness Questionnaire (MEQ), the Epworth Sleepiness Scale, the Athens Insomnia Scale and the Pittsburgh Sleep Quality Index.Results: According to MEQ scores patients were classified in three groups: a) eveningness (n = 18), b) neither (n = 61) and c) morningness type (n = 21). The age was different among chronotypes, being morningness-type patients older. The eveningness-type group showed higher scores in suicidal thoughts, more impaired work and activities, higher paranoid symptoms, higher scores on the anxiety cluster (HRSD), while the morningness-type group showed lower proportion of melancholic symptoms (MINI). We did not find association between sleep parameters and specific chronotypes.Limitations: The relatively small sample size and the concurrent assessment of chronotypes and depression may have biased our findings.Conclusions: Our data suggest the idea that chronotypes have an impact on depressive episodes features, with higher severity for the eveningness-type. (C) 2009 Elsevier B.V. All rights reserved.