Evolving research trends in bioinformatics
Evolving research trends in bioinformatics
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DOI：
10.1093/bib/bbl035
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发表时间：
2007-03-01
影响因子：
9.5
通讯作者：
Wren, Jonathan D.
中科院分区：
文献类型：
--
作者：
Perez-Iratxeta, Carolina;Andrade-Navarro, Miguel A.;Wren, Jonathan D.
生物信息学的跨学科性质需要与其他生物医学学科共同进化，因此一些生物信息学应用在某些学科中变得流行，反过来，这些学科影响了未来生物信息学发展努力的重点。我们在这里观察到，各种生物医学学科中计算方法的增长不仅仅是计算机和互联网广泛使用的反映，而且是由于对生物医学科学界其他领域有用的生物信息学数据库和方法的产生。我们使用存储在MEDLINE生物医学文献数据库和美国国立卫生研究院资助项目赠款中的摘要来量化两种效应。首先，我们将生物医学文献作为一个整体进行了研究，发现在过去的三十年中，计算方法的使用在生物医学学科中变得越来越普遍，而数据库和互联网的使用在过去的十年中也迅速增加。其次，我们研究了生物信息学主题使用的最新趋势。我们观察到分子序列数据库是生物信息学领域广泛采用的生物医学贡献，而微阵列分析是生物信息学领域所从事的主要新课题之一。通过这一分析，我们能够确定在使用信息学来帮助课程规划、计算基础设施的开发以及劳动力教育和资金战略方面快速增长的领域。
The cross-disciplinary nature of bioinformatics entails co-evolution with other biomedical disciplines, whereby some bioinformatics applications become popular in certain disciplines and, in turn, these disciplines influence the focus of future bioinformatics development efforts. We observe here that the growth of computational approaches within various biomedical disciplines is not merely a reflection of a general extended usage of computers and the Internet, but due to the production of useful bioinformatics databases and methods for the rest of the biomedical scientific community. We have used the abstracts stored both in the MEDLINE database of biomedical literature and in NIH-funded project grants, to quantify two effects. First, we examine the biomedical literature as a whole and find that the use of computational methods has become increasingly prevalent across biomedical disciplines over the past three decades, while use of databases and the Internet have been rapidly increasing over the past decade. Second, we study the recent trends in the use of bioinformatics topics. We observe that molecular sequence databases are a widely adopted contribution in biomedicine from the field of bioinformatics, and that microarray analysis is one of the major new topics engaged by the bioinformatics community. Via this analysis, we were able to identify areas of rapid growth in the use of informatics to aid in curriculum planning, development of computational infrastructure and strategies for workforce education and funding.