Loss of putative GABAergic neurons in the ventrolateral medulla in multiple system atrophy.
Loss of putative GABAergic neurons in the ventrolateral medulla in multiple system atrophy.
复制标题
多系统萎缩中腹外侧髓质中假定的 GABA 能神经元的丧失。
DOI：
10.1093/sleep/zsab074
复制
发表时间：
2021
期刊：
影响因子：
5.6
通讯作者：
Benarroch,EduardoE
中科院分区：
文献类型：
--
作者：
Schmeichel,AnnM;Coon,ElizabethA;Parisi,JosephE;Singer,Wolfgang;Low,PhillipA;Benarroch,EduardoE
研究目的多系统萎缩（MSA）与心血管、睡眠和呼吸控制障碍有关。延髓腹外侧（VLM）的外侧巨细胞旁核（LPGi）含有GABA能神经元，参与控制快速眼动（REM）睡眠和心迷走神经反应。我们试图确定是否有损失的假定GABA能神经元的LPGi和邻近地区在MSA.MethodsSections的髓质进行处理GAD 65/67免疫反应性在8例临床和神经病理诊断MSA和6个对照组。这些推定的GABA能LPGi神经元映射基于他们的关系，以相邻的单胺能VLM groups.ResultsThere是显着减少的GAD-免疫反应阳性神经元的数目在LPGi和相邻的VLM区域在MSA. Conclusions有损失的GABA能神经元在VLM，包括LPGi在患者与MSA。而这些发现提供了一个可能的机制基板，考虑到少数情况下，进一步的研究是必要的，以确定他们是否有助于快速眼动睡眠相关的心迷走神经和可能的呼吸失调的MSA。
Study ObjectivesMultiple system atrophy (MSA) is associated with disturbances in cardiovascular, sleep and respiratory control. The lateral paragigantocellular nucleus (LPGi) in the ventrolateral medulla (VLM) contains GABAergic neurons that participate in control of rapid eye movement (REM) sleep and cardiovagal responses. We sought to determine whether there was loss of putative GABAergic neurons in the LPGi and adjacent regions in MSA.MethodsSections of the medulla were processed for GAD65/67 immunoreactivity in eight subjects with clinical and neuropathological diagnosis of MSA and in six control subjects. These putative GABAergic LPGi neurons were mapped based on their relationship to adjacent monoaminergic VLM groups.ResultsThere were markedly decreased numbers of GAD-immunoreactive neurons in the LPGi and adjacent VLM regions in MSA.ConclusionsThere is loss of GABAergic neurons in the VLM, including the LPGi in patients with MSA. Whereas these findings provide a possible mechanistic substrate, given the few cases included, further studies are necessary to determine whether they contribute to REM sleep-related cardiovagal and possibly respiratory dysregulation in MSA.