Magnetization Exchange With Water and T1 Relaxation of the Downfield Resonances in Human Brain Spectra at 3.0 T
Magnetization Exchange With Water and T1 Relaxation of the Downfield Resonances in Human Brain Spectra at 3.0 T
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DOI：
10.1002/mrm.22813
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发表时间：
2011-05-01
影响因子：
3.3
通讯作者：
Kreis, Roland
中科院分区：
文献类型：
--
作者：
MacMillan, Erin L.;Chong, Daniel G. Q.;Kreis, Roland
在活体质子磁共振波谱中使用水抑制降低了与水进行磁化交换的共振的信号强度，特别是那些水的下场。为了研究这些可交换的共振，利用代谢产物循环技术对11名健康志愿者在3.0T下的一个大的脑体素的磁共振波谱进行了反转转移实验，发现水在场下最显著的峰的交换率在0.5ms到8.9mS(-1)之间，而在没有交换的情况下T-1弛豫时间在175ms到525ms之间。这些发现可能有助于指定下场共振和更好地理解化学交换饱和转移成像中的对比度来源。Magn Reson Med 65：1239-1246,2011。(C)2011年Wiley-Liss，Inc.
The use of water suppression for in vivo proton MR spectroscopy diminishes the signal intensities from resonances that undergo magnetization exchange with water, particularly those downfield of water. To investigate these exchangeable resonances, an inversion transfer experiment was performed using the metabolite cycling technique for non-water-suppressed MR spectroscopy from a large brain voxel in 11 healthy volunteers at 3.0 T. The exchange rates of the most prominent peaks downfield of water were found to range from 0.5 to 8.9 s(-1), while the T-1 relaxation times in absence of exchange were found to range from 175 to 525 ms. These findings may help toward the assignments of the downfield resonances and a better understanding of the sources of contrast in chemical exchange saturation transfer imaging. Magn Reson Med 65:1239-1246, 2011. (c) 2011 Wiley-Liss, Inc.