Disordered domains and high surface charge confer hubs with the ability to interact with multiple proteins in interaction networks
Disordered domains and high surface charge confer hubs with the ability to interact with multiple proteins in interaction networks
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DOI：
10.1016/j.febslet.2006.03.003
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发表时间：
2006-04-03
期刊：
影响因子：
3.5
通讯作者：
Nakamura, H
中科院分区：
文献类型：
--
作者：
Patil, A;Nakamura, H
我们研究了中枢的结构特性，使它们能够与蛋白质-蛋白质相互作用网络中的多个伙伴相互作用。我们发现，与非集线器相比，集线器具有更多观察到和预测的无序残基，具有更少的环/线圈，并且表面上的带电残基更多。较小的中心比较大的中心有更少的无序残基和更多的表面带电残基。我们的结论是，无序结构域提供的整体灵活性和高表面电荷是互补因素，在中枢的结合能力中发挥着重要作用。 (c) 2006 年欧洲生化学会联合会。由 Elsevier B.V. 出版。保留所有权利。
We investigate the structural properties of hubs that enable them to interact with several partners in protein-protein interaction networks. We find that hubs have more observed and predicted disordered residues with fewer loops/coils, and more charged residues on the surface as compared to non-hubs. Smaller hubs have fewer disordered residues and more charged residues on the surface than larger hubs. We conclude that the global flexibility provided by disordered domains, and high surface charge are complementary factors that play a significant role in the binding ability of hubs. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.