ASSOCIATIVE RETUNING IN THE THALAMIC SOURCE OF INPUT TO THE AMYGDALA AND AUDITORY-CORTEX - RECEPTIVE-FIELD PLASTICITY IN THE MEDIAL DIVISION OF THE MEDIAL GENICULATE-BODY
ASSOCIATIVE RETUNING IN THE THALAMIC SOURCE OF INPUT TO THE AMYGDALA AND AUDITORY-CORTEX - RECEPTIVE-FIELD PLASTICITY IN THE MEDIAL DIVISION OF THE MEDIAL GENICULATE-BODY
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DOI：
10.1037/0735-7044.106.1.81
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发表时间：
1992-02-01
影响因子：
1.9
通讯作者：
WEINBERGER, NM
中科院分区：
文献类型：
--
作者：
EDELINE, JM;WEINBERGER, NM
内侧膝状体（MGm）的内侧部分投射到外侧杏仁核和听觉皮层上层，并在经典调节过程中迅速发展生理可塑性。学习对豚鼠 MGm 频率感受野 (RF) 的影响已经确定。经典条件反射（音调足部电击），以条件性心动过缓的快速发展为标志，产生了条件刺激（CS）频率特定的射频可塑性：在立即和 1 小时保留期后，CS 频率的响应增加，而其他频率的响应减少。敏化训练只产生了 RF 的一般变化。这些发现是参考杏仁核介导的恐惧条件反应的引发以及获取过程中听觉皮层中存储的信息的检索机制来考虑的。
The medial division of the medial geniculate body (MGm) projects to the lateral amygdala and the upper layer of auditory cortex and develops physiological plasticity rapidly during classical conditioning. The effects of learning on frequency receptive fields (RFs) in the MGm of the guinea pig have been determined. Classical conditioning (tone-footshock), as indexed by rapid development of conditioned bradycardia, produced conditioned stimulus (CS)-frequency specific RF plasticity: increased response at the CS frequency with decreased responses at other frequencies, both immediately and after a 1-hr retention period. Sensitization training produced only general changes in RFs. These findings are considered with reference to both the elicitation of amygdala-mediated, fear-conditioned responses and the mechanism of retrieval of information stored in the auditory cortex during acquisition.