Detection of virus‐specific DNA and RNA base‐sequences in individual cells transformed or infected by adenovirus type 2
Detection of virus‐specific DNA and RNA base‐sequences in individual cells transformed or infected by adenovirus type 2
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检测被 2 型腺病毒转化或感染的单个细胞中的病毒特异性 DNA 和 RNA 碱基序列
DOI：
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发表时间：
1975
影响因子：
6.4
通讯作者：
K. Jones
中科院分区：
文献类型：
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作者：
M. Moar;K. Jones
通过 3H 胸苷标记的腺病毒 2 DNA，腺病毒特异性 DNA 序列已定位于腺病毒 2 或 12 感染细胞的单个细胞核中，并且在允许的细胞以及腺病毒 2 型转化的细胞中检测到腺病毒特异性 RNA 序列。检测此类特定病毒 RNA 碱基序列的能力，特别是通过原位杂交，应有助于研究转录肿瘤和肿瘤的特异性。
By means of 3H thymidine‐labelled adenovirus 2 DNA, adenovirus‐specific DNA sequences have been localized in individual nuclei of adenovirus 2‐ or 12‐infected cells, and adenovirus‐specific RNA sequences have been detected in the permissive cells as well as in cells transformed by adenovirus type 2. The ability to detect such specific virus RNA base‐sequences in particular, by in situ hybridization, should be useful in studying the transcriptional specificities of tumours and neoplasms.