Influenza vaccination responses: Evaluating impact of repeat vaccination among health care workers
Influenza vaccination responses: Evaluating impact of repeat vaccination among health care workers
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DOI：
10.1016/j.vaccine.2017.03.063
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发表时间：
2017-05-02
期刊：
影响因子：
5.5
通讯作者：
Sullivan, Sheena G.
中科院分区：
文献类型：
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作者：
Leung, Vivian K. Y.;Carolan, Louise A.;Sullivan, Sheena G.
目的：比较多次接种疫苗（高接种率组）和较少接种疫苗（低接种率组）的卫生保健工作者（HCWs）对流感的抗体反应。设计：前瞻性血清调查。环境：三级转诊医院。参与者：医护人员。方法：对卫生保健工作者接种2015年南半球三价流感疫苗。分别在接种前、接种后21-28天和接种后6个月检测流感抗体滴度。采用血凝抑制试验测定抗体滴度。计算血清阳性水平和估计几何平均滴度。结果：纳入的202名卫生保健员中，182名完成了研究（143名高接种率，39名低接种率）。两个疫苗接种组均表现出疫苗接种后几何平均滴度的增加，低疫苗接种组的增加更大。疫苗接种后，高接种率组和低接种率组血清阳性率均保持较高水平。低疫苗接种率组的HCWs中，H3N2成分的感染率最高。结论：在我们的研究中，高接种组和低接种组在接种后都显示出保护性抗体滴度。目前的研究结果表明，在高度接种疫苗的卫生保健工作者中，血清学反应降低。在做出任何政策改变之前，需要进行更多样本量更大的研究，并对未接种疫苗和曾经接种过疫苗的人群进行更多的研究，以证实或反驳这些发现。(C) 2017 Elsevier Ltd.版权所有。
Objective: To compare the antibody response to influenza between health care workers (HCWs) who have received multiple vaccinations (high vaccination group) and those who have received fewer vaccinations (low vaccination group).Design: Prospective serosurvey.Setting: Tertiary referral hospital.Participants: Healthcare workers.Methods: Healthcare workers were vaccinated with the 2015 southern hemisphere trivalent influenza vaccine. Influenza antibody titres were measured pre-vaccination, 21-28 days post-vaccination and 6 months post-vaccination. Antibody titres were measured using the haemagglutination inhibition assay. Levels of seropositivity and estimated geometric mean titres were calculated.Results: Of the 202 HCWs enrolled, 182 completed the study (143 high vaccination and 39 low vaccination). Both vaccination groups demonstrated increases in post-vaccination geometric mean titres, with greater gains in the low vaccination group. Seropositivity remained high in both high and low vaccination groups post-vaccination. The highest fold rise was observed among HCWs in the low vaccination group against the H3N2 component of the vaccine.Conclusions: Both high and low vaccination groups in our study demonstrated protective antibody titres post-vaccination. The findings from the current study are suggestive of decreased serological response among highly vaccinated HCWs. More studies with larger sample sizes and a greater number of people in the vaccine-naive and once-vaccinated groups are required to confirm or refute these findings before making any policy changes. (C) 2017 Elsevier Ltd. All rights reserved.