RELATIONSHIP OF PLASMA GROWTH HORMONE-RELEASING HORMONE LEVELS TO PUBERTAL CHANGES
RELATIONSHIP OF PLASMA GROWTH HORMONE-RELEASING HORMONE LEVELS TO PUBERTAL CHANGES
复制标题
DOI：
10.1210/jcem-63-3-680
复制
发表时间：
1986-09-01
影响因子：
5.8
通讯作者：
DONNADIEU, M
中科院分区：
文献类型：
--
作者：
ARGENTE, J;EVAINBRION, D;DONNADIEU, M
通过 RIA 测量了 180 名正常受试者（8 至 18 岁之间的 93 名男孩和 87 名女孩）的基础血浆 GH 释放激素 (GHRH) 浓度。每个受试者都身体健康，身高在 -2 到 +2 SD 之间。还对十四名青春期延迟的男孩进行了研究。青春期期间血浆 GHRH 浓度高于青春期之前。青春期中期，女孩的平均 GHRH 水平为 159.1 .+-。 28.5 (.+-. SEM) pg/ml，比青春期前女孩的水平 (30.3 .+-. 4.3 pg/ml) 高约 5 倍。青春期中期男孩的平均血浆 GHRH (101.4.+-.11.5 pg/ml) 比青春期前男孩的水平 (48.1.+-.5.2 pg/ml) 高约 2 倍。与年龄相似的男孩相比，青春期延迟男孩的 GHRH 水平与处于相似青春期阶段的男孩的 GHRH 水平更相似。青春期血浆 GHRH 水平的急剧上升表明这种肽在青少年生长突增中发挥着重要作用。此外，这些数据表明青春期期间的 GHRH 水平可能是患者青春期发育的标志。
Basal plasma GH-releasing hormone (GHRH) concentrations were measured by RIA in 180 normal subjects (93 boys and 87 girls between the ages of 8 and 18 yr). Every subject was in good health and between -2 and +2 SD for height. Fourteen boys with delayed puberty also were studied. Plasma GHRH concentrations were higher during puberty than before it. At midpuberty, the mean GHRH levels in girls was 159.1 .+-. 28.5 (.+-. SEM) pg/ml, approximately 5-fold higher than the level in prepubertal girls (30.3 .+-. 4.3 pg/ml). The mean plasma GHRH in midpubertal boys (101.4 .+-. 11.5 pg/ml) was approximately 2-fold higher than the level in prepubertal boys (48.1 .+-. 5.2 pg/ml). The GHRH levels in boys with delayed puberty more closely resembled those in boys at a similar pubertal stage than those in boys of similar chronological age. The dramatic rise in plasma GHRH levels during puberty suggests a role for this peptide in the adolescent growth spurt. Moreover, these data indicate that GHRH levels during adolescence may be a marker of the patient''s pubertal development.