Green Organic Chemistry: Strategies, Tools, and Laboratory Experiments
Green Organic Chemistry: Strategies, Tools, and Laboratory Experiments
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绿色有机化学：策略、工具和实验室实验
DOI：
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发表时间：
2003
期刊：
影响因子：
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通讯作者：
J. Hutchison
中科院分区：
文献类型：
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作者：
K. Doxsee;J. Hutchison
简要目录。实验的图形摘要。1.导论. 2.化学危害的识别和评价。3.化学品暴露和环境污染。4.有关化学危害的信息来源。5.绿色化学导论。6.替代溶剂。7.替代试剂。8.反应设计和效率。9.替代原料和产品。10.大图片和绿色化学计量。实验室实验。11.实验部分前言。实验1：无溶剂反应：Aldol反应。实验2：烯烃的溴化：二苯乙烯二溴化物的制备。实验3：二苯乙烯的更绿色的溴化。实验4：环己烯的制备和蒸馏。实验5：己二酸的合成和再结晶。实验6：炔的氧化偶联：Spider-Eglinton-Hay偶联。实验7：5，10，15，20-四苯基卟啉的气相合成、柱色谱和可见光谱。实验8：5，10，15，20-四苯基卟啉的微波合成。实验9：5，10，15，20-四苯基卟啉的代谢。实验10：测量溶剂效应：叔丁基氯水解的动力学。实验11：分子力学建模。实验12：亲电芳香族碘化。实验13：钯催化的炔偶联/分子内炔加成：天然产物合成。实验14：基于树脂的氧化化学。实验15：羰基化学：硫胺介导的糠醛的苯偶姻缩合。实验16：固相光化学。实验17：有机化学的应用：用分子膜图案化表面。实验18：傅克反应：二茂铁的乙酰化。实验19：组合化学：抗生素药物发现。附录A：绿色化学的十二项原则。
Brief Table of Contents. Graphical Abstracts for the Experiments. 1. INTRODUCTION. 2. IDENTIFICATION AND EVALUATION OF CHEMICAL HAZARDS. 3. CHEMICAL EXPOSURE AND ENVIRONMENTAL CONTAMINATION. 4. SOURCES OF INFORMATION ABOUT CHEMICAL HAZARDS. 5. INTRODUCTION TO GREEN CHEMISTRY. 6. ALTERNATIVE SOLVENTS. 7. ALTERNATIVE REAGENTS. 8. REACTION DESIGN AND EFFICIENCY. 9. ALTERNATIVE FEEDSTOCKS AND PRODUCTS. 10. THE BIG PICTURE AND GREEN CHEMISTRY METRICS. Laboratory Experiments. 11. PREFACE TO THE EXPERIMENTAL SECTION. Experiment 1: Solventless Reactions: The Aldol Reaction. Experiment 2: Bromination of An Alkene: Preparation of Stilbene Dibromide. Experiment 3: A Greener Bromination of Stilbene. Experiment 4: Preparation and Distillation of Cyclohexene. Experiment 5: Synthesis and Recrystallization of Adipic Acid. Experiment 6: Oxidative Coupling of Alkynes: The Glaser-Eglinton-Hay Coupling. Experiment 7: Gas-Phase Synthesis, Column Chromatography and Visible Spectroscopy of 5,10,15,20-Tetraphenylporphyrin. Experiment 8: Microwave Synthesis of 5,10,15,20-Tetraphenylporphyrin. Experiment 9: Metallation of 5,10,15,20-Tetraphenylporphyrin. Experiment 10: Measuring Solvent Effects: Kinetics of Hydrolysis of tert-Butyl Chloride. Experiment 11: Molecular Mechanics Modeling. Experiment 12: Electrophilic Aromatic Iodination. Experiment 13: Palladium-Catalyzed Alkyne Coupling/Intramolecular Alkyne Addition: Natural Product Synthesis. Experiment 14: Resin-Based Oxidation Chemistry. Experiment 15: Carbonyl Chemistry: Thiamine-Mediated Benzoin Condensation of Furfural. Experiment 16: Solid-Phase Photochemistry. Experiment 17: Applications of Organic Chemistry: Patterning Surfaces With Molecular Films. Experiment 18: The Friedel-Crafts Reaction: Acetylation of Ferrocene. Experiment 19: Combinatorial Chemistry: Antibiotic Drug Discovery. Appendix A: The Twelve Principles of Green Chemistry.