A potential novel pathological implication of serum soluble triggering receptor expressed on myeloid cell 2 in insulin resistance in a general Japanese population: The Hisayama study
A potential novel pathological implication of serum soluble triggering receptor expressed on myeloid cell 2 in insulin resistance in a general Japanese population: The Hisayama study
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DOI：
10.1016/j.diabres.2018.10.007
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发表时间：
2018-12-01
影响因子：
5.1
通讯作者：
Ninomiya, Toshiharu
中科院分区：
文献类型：
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作者：
Tanaka, Masashi;Honda, Takanori;Ninomiya, Toshiharu
目的：尚未有队列研究探讨在普通人群中触发髓系细胞表面表达的受体TREM2及其可溶性形式sTREM2在胰岛素抵抗中的病理学意义。方法：根据血清sTREM2浓度四分位数，将2742名40岁的日本社区居民分为4组。我们检验了sTREM2水平与人体测量参数和胰岛素抵抗的稳态模型评估(HOMA-IR)的横断面相关性。结果：sTREM2浓度的中位数为255.6(四分位数范围，162.5-419.2)pg/mL。在多因素分析中，腰围和脂肪质量指数随着sTREM2水平的升高而增加(趋势P值分别为0.001和0.02)，但sTREM2水平与体重指数和脱脂体重指数之间没有显著关联。在未服用抗糖尿病药物的受试者中(n=2610)，即使在调整了腰围、脂肪质量指数和高敏C反应蛋白后，sTREM2水平仍与较高的HOMA-IR相关(P=0.001)。结论：我们的研究结果表明，血清sTREM2在胰岛素抵抗中具有新的病理作用，而肥胖和炎症对sTREM2与胰岛素抵抗的关系没有实质性影响。(C)2018爱思唯尔B.V.保留所有权利。
Aims: No cohort study has examined the pathological significance of triggering receptor expressed on myeloid cell 2 (TREM2), a cell surface receptor expressed on myeloid lineage cells, and its soluble form, sTREM2, in insulin resistance in a general population.Methods: A total of 2742 community-dwelling Japanese individuals aged >= 40 years were divided into 4 groups according to the serum sTREM2 concentration quartiles. We examined the cross-sectional association of sTREM2 levels with anthropometric parameters and the homeostasis model assessment of insulin resistance (HOMA-IR).Results: The median sTREM2 concentrations was 255.6 (interquartile range, 162.5-419.2) pg/mL. In multivariate analyses, waist circumference and fat mass index increased with elevating sTREM2 levels (P for trend: < 0.001 and 0.02, respectively), but there was no significant association between sTREM2 levels and body mass index and fat-free mass index. Among the subjects without taking antidiabetic medications (n = 2610), greater sTREM2 levels were associated with higher HOMA-IR (P for trend < 0.001) even after adjusting for waist circumference, fat mass index, and high-sensitivity C-reactive protein.Conclusions: Our findings suggest that serum sTREM2 had novel pathological roles in insulin resistance, while obesity and inflammation had no substantial effects on the relationship between sTREM2 and insulin resistance in this cohort. (C) 2018 Elsevier B.V. All rights reserved.