Supply-Side Drug Policy in the Presence of Substitutes: Evidence from the Introduction of Abuse-Deterrent Opioids
Supply-Side Drug Policy in the Presence of Substitutes: Evidence from the Introduction of Abuse-Deterrent Opioids
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DOI：
10.1257/pol.20170082
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发表时间：
2018-11-01
影响因子：
5.3
通讯作者：
Pacula, Rosalie Liccardo
中科院分区：
文献类型：
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作者：
Alpert, Abby;Powell, David;Pacula, Rosalie Liccardo
1999年至2010年，处方阿片类止痛药过量死亡人数几乎翻了两番。我们研究了迄今为止可滥用阿片类药物最大的供应中断之一的后果-2010年推出了一种具有滥用威慑作用的奥施康定版本。限制获得阿片类药物的供应方干预措施可能会产生增加包括海洛因在内的替代药物使用的意想不到的后果。利用OxyContin暴露的跨州差异，我们发现OxyContin滥用的初始比率最高的州经历了海洛因死亡的最大增长。我们的结果表明，最近的海洛因流行在很大程度上是由于奥施康定的重新合成。
Overdose deaths from prescription opioid pain relievers nearly quadrupled between 1999 and 2010. We study the consequences of one of the largest supply disruptions to date to abusable opioids-the introduction of an abuse-deterrent version of OxyContin in 2010. Supply-side interventions that limit access to opioids may have the unintended consequence of increasing use of substitute drugs, including heroin. Exploiting cross-state variation in OxyContin exposure, we find that states with the highest initial rates of OxyContin misuse experienced the largest increases in heroin deaths. Our results imply that the recent heroin epidemic is largely due to the reformulation of OxyContin.