Psychosocial and neurocognitive functioning in unipolar and bipolar depression: A 12-month prospective study
Psychosocial and neurocognitive functioning in unipolar and bipolar depression: A 12-month prospective study
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DOI：
10.1016/j.psychres.2011.09.013
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发表时间：
2012-03-30
影响因子：
11.3
通讯作者：
Lafleur, Martin F.
中科院分区：
文献类型：
--
作者：
Godard, Julie;Baruch, Philippe;Lafleur, Martin F.
之前的研究表明，单相和双相抑郁症患者会出现心理社会和认知障碍，即使在亚综合征和正常心境状态下也会持续存在。目前，人们对抑郁症患者心理社会和认知缺陷的性质和程度知之甚少。本研究的目的是描述单相（MOD）和双相（BD）患者在重度抑郁发作期间的社会心理和认知特征，并比较患者组的特征。抑郁症患者MDD（n=13）和BD（n=11）进行了为期12个月的随访。在基线和6周、4个月、8个月和12个月随访时进行临床、社会心理和神经心理评估。在严重情绪障碍的情况下，在抑郁发作期间，MDD和BD患者的心理社会和神经认知功能似乎相似。所有MDD和BD患者都有整体心理社会功能障碍，以职业和关系障碍为特征。此外，神经认知方面的性质和认知缺陷的程度是异质性的，但注意力的过程经常受到损害。治疗1年后，职业和关系障碍以及神经认知功能障碍持续存在，足以改变日常功能。皇冠版权所有（C）2012由爱思唯尔爱尔兰有限公司出版。保留所有权利。
Previous studies have revealed psychosocial and cognitive impairments in patients during unipolar and bipolar depression, which persist even in subsyndromal and euthymic states. Currently, little is known about the nature and the extent of psychosocial and cognitive deficits during depression. The aim of the present study was to characterize psychosocial and cognitive profiles among unipolar (MOD) and bipolar (BD) patients during a major depressive episode and to compare the profiles of the patient groups. Depressed patients with MDD (n=13) and BD (n=11) were followed over a period of 12 months. Clinical, psychosocial and neuropsychological assessments were conducted at baseline and at 6-week, 4-month, 8-month and 12-month follow-ups. In the case of severe mood disorders, psychosocial and neurocognitive functioning seem similar among MDD and BD patients during a depressive episode. All MDD and BD patients had global psychosocial dysfunction, characterized by occupational and relational impairments. Furthermore, the neurocognitive profile was heterogeneous with regard to the nature and extent of cognitive deficits but attentional processes were frequently compromised. After 1 year of treatment, occupational and relational impairments, as well as neurocognitive dysfunction, persisted sufficiently to alter daily functioning. Crown Copyright (C) 2012 Published by Elsevier Ireland Ltd. All rights reserved.