Immune system-dependent and -independent replication of the scrapie agent
Immune system-dependent and -independent replication of the scrapie agent
复制标题
痒病因子的免疫系统依赖性和非依赖性复制
作者：
C. Lasmézas;J. Cesbron;J. Deslys;R. Demaimay;K. Adjou;René Rioux;C. Lemaire;C. Locht;D. Dormont
利用严重联合免疫缺陷（SCID）小鼠模型，我们研究了外周接种后瘙痒病发展的免疫系统需求。总共有33%的SCID小鼠，除了一只免疫重建的SCID小鼠（93%）之外的所有小鼠，以及所有CB17对照小鼠都发生了这种疾病。PrPres在所有患病动物的脑中以及在重建的SCID和CB 17对照小鼠的脾脏中可检测到，但在患病的非免疫重建的SCID小鼠中不可检测到。免疫系统似乎是羊瘙痒病发病机制的主要靶点，但也可能通过内脏神经纤维从腹膜直接传播到中枢神经系统。
Using the severe combined immunodeficiency (SCID) mouse model, we investigated the requirement of the immune system for the development of scrapie after peripheral inoculation. A total of 33% of SCID mice, all but one immunologically reconstituted SCID mice (93%), and all CB17 control mice developed the disease. PrPres was detectable in the brains of all diseased animals and in the spleens of reconstituted SCID and CB17 control mice but not of the diseased non-immunologically reconstituted SCID mice. The immune system appears to be a primary target in the pathogenesis of scrapie, but direct spread to the central nervous system from the peritoneum via visceral nerve fibers can probably also occur.
诱导严重联合免疫缺陷小鼠功能性滤泡树突状细胞发育。
DOI：
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发表时间：
1993
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Kapasi,ZF;Burton,GF;Shultz,LD;Tew,JG;Szakal,AK
通讯作者：
Szakal,AK
影响因子：
56.9
作者：
BOLTON, DC;MCKINLEY, MP;PRUSINER, SB
通讯作者：
PRUSINER, SB