Elevated cord blood IgE is associated with recurrent wheeze and atopy at 7 yrs in a high risk cohort
Elevated cord blood IgE is associated with recurrent wheeze and atopy at 7 yrs in a high risk cohort
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DOI：
10.1111/j.1399-3038.2009.00869.x
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发表时间：
2009-12-01
影响因子：
4.4
通讯作者：
Chan-Yeung, Moira
中科院分区：
文献类型：
--
作者：
Ferguson, Alexander;Dimich-Ward, Helen;Chan-Yeung, Moira
有相当大的兴趣，在确定儿童的高风险发展为过敏性疾病的初级预防。本研究评估了可检测到的脐带血IgE的危险因素，并评估了CB-IgE在预测哮喘和其他IgE介导的过敏性疾病的高风险儿童，因为家族史。脐带血作为随机对照试验的一部分，评估干预计划在IgE介导的过敏性疾病的一级预防中的有效性。测量CB-IgE，并评估其与围产期危险因素的相关程度。然后在7岁时评估该队列的特应性疾病，以评估CB-IgE的预测价值。55名（19.3%）婴儿可检测到CB-IgE（>= 0.5 kU/l）。母亲的特应性和出生在冬季是与可检测到的CB-IgE相关的危险因素。发现CB-IgE与过敏性致敏（OR 2.22; 95%CI 1.11，4.41）和7年时的复发性喘息（OR 2.51，95%CI 1.09，5.76）显著相关，但与其他结局无关。CB-IgE可能是一个有用的措施，以确定儿童在高风险的特应性疾病的一级预防的目的。
There is considerable interest in identifying children at high risk for developing atopic diseases for primary prevention. This study evaluates risk factors for detectable cord blood IgE and assesses CB-IgE in predicting asthma and other IgE-mediated allergic diseases in children at high risk because of family history. Cord blood was obtained as part of a randomized controlled trial assessing the efficacy of an intervention program in the primary prevention of IgE-mediated allergic diseases. CB-IgE was measured and the degree to which this was associated with perinatal risk factors was assessed. The cohort was then evaluated for atopic disorders at 7 yrs of age to assess the predictive value of CB-IgE. Fifty-five (19.3%) of infants had detectable CB-IgE (>= 0.5 kU/l). Maternal atopy and birth in winter months were risk factors associated with detectable CB-IgE. CB-IgE was found to be significantly associated with allergic sensitization (OR 2.22; 95% CI 1.11, 4.41) and recurrent wheeze at 7 yrs (OR 2.51, 95% CI 1.09, 5.76) but not with other outcomes. CB-IgE may be a useful measure for identifying children at high risk of atopic diseases for the purpose of primary prevention.