Refining the depression-nicotine dependence link: Patterns of depressive symptoms in psychiatric outpatients with current, past, and no history of nicotine dependence
Refining the depression-nicotine dependence link: Patterns of depressive symptoms in psychiatric outpatients with current, past, and no history of nicotine dependence
复制标题
DOI：
10.1016/j.addbeh.2008.11.008
复制
发表时间：
2009-03-01
影响因子：
4.4
通讯作者：
Zimmerman, Mark
中科院分区：
文献类型：
--
作者：
Leventhal, Adam M.;Kahler, Christopher W.;Zimmerman, Mark
本研究的目的是通过评估哪些特定的抑郁症状与精神科门诊患者的尼古丁依赖唯一相关来阐明抑郁与尼古丁依赖的联系。参与者进行了评估，使用结构化的临床访谈，产生精神病诊断和各种抑郁症状的临床评级。比较了三组的抑郁症状：（1）无尼古丁依赖史的患者（NND; n = 1015）;（2）过去尼古丁依赖完全缓解至少2个月的患者（PND; n = 211）;和（3）当前尼古丁依赖的患者（CND：n = 342）。与NND患者和PND患者（程度较轻）相比，CND参与者的某些典型植物人、精神病和烦躁抑郁症状升高。抑郁情绪、快感缺乏、食欲/体重减轻、精神障碍、疲劳和失眠的组间差异最一致。非典型症状的差异最不明显。PND和NND患者的症状特征几乎无法区分。某些植物性、神经性和烦躁性抑郁症状与尼古丁依赖密切相关，可能在抑郁-尼古丁依赖共病中起重要的病因作用。(C)2008爱思唯尔有限公司保留所有权利。
The aim of this study was to elucidate the depression-nicotine dependence link by evaluating which specific depressive symptoms are uniquely associated with nicotine dependence in psychiatric outpatients. Participants were assessed using structured clinical interviews which yielded psychiatric diagnoses and clinical ratings on a wide variety of depressive symptoms. Depressive symptoms were compared across three groups: (1) patients with no history of nicotine dependence (NND; n = 1015); (2) patients with past nicotine dependence in full remission for at least 2 months (PND; n = 211); and (3) patients with current nicotine dependence (CND: n = 342). Participants with CND evidenced elevations on certain typical-vegetative, melancholic, and dysphoric depressive symptoms as compared to patients with NND and (to a lesser extent) patients with PND. Group differences were most consistent for depressed mood, anhedonia, appetite/weight loss, psychomotor disturbance, fatigue, and insomnia. Differences were least apparent for atypical symptoms. The symptomatic profiles of PND and NND patients were virtually indistinguishable. Certain vegetative, melancholic and dysphoric depressive symptoms are closely associated with nicotine dependence and could play an important etiological role in depression-nicotine dependence comorbidity. (C) 2008 Elsevier Ltd. All rights reserved.