A Practical Guide to Whole Slide Imaging A White Paper From the Digital Pathology Association
A Practical Guide to Whole Slide Imaging A White Paper From the Digital Pathology Association
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DOI：
10.5858/arpa.2018-0343-ra
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发表时间：
2019-02-01
影响因子：
4.6
通讯作者：
Hartman, Douglas, I
中科院分区：
文献类型：
--
作者：
Zarella, Mark D.;Bowman, Douglas;Hartman, Douglas, I
上下文。-全幻灯片成像（WSI）代表了病理学范式的转变，是广泛的数字工具进入该领域的必要的第一步。它的基本功能是将玻片数字化，但它对病理工作流程、可重复性、教育材料的传播、向贫困地区扩展服务以及机构内和机构间合作的影响是一项具有深远影响的重大创新运动的例证。尽管WSI对病理学实践、学术中心和研究机构有很多好处，但实施的复杂性仍然是广泛采用的障碍。随着美国首次批准将WSI用于初级诊断，采用WSI的一些障碍已经下降。然而，对于许多机构来说，实施WSI仍然是一个困难的前景，特别是那些不熟悉实施系统所必需的技术的利益相关者，或者不能有效地与执行领导和发起人沟通技术的好处，这些技术可能缺乏明确和即时的补偿机会。-概述WSI技术的现状和未来，并展示WSI在病理学实践、医学教育、研究和合作方面的几个直接应用。数据源。-同行评议文献由具有wsi实践知识和经验的病理学家、科学家和技术专家进行评审。实施WSI是一项多方面的、本质上是多学科的努力，需要病理学家、技术专家和行政领导的贡献。更好地了解当前实现的挑战，以及该技术的好处和成功，可以帮助潜在用户确定成功的最佳途径。
Context.-Whole slide imaging (WSI) represents a paradigm shift in pathology, serving as a necessary first step for a wide array of digital tools to enter the field. Its basic function is to digitize glass slides, but its impact on pathology workflows, reproducibility, dissemination of educational material, expansion of service to underprivileged areas, and intrainstitutional and interinstitutional collaboration exemplifies a significant innovative movement with far-reaching effects. Although the benefits of WSI to pathology practices, academic centers, and research institutions are many, the complexities of implementation remain an obstacle to widespread adoption. In the wake of the first regulatory clearance of WSI for primary diagnosis in the United States, some barriers to adoption have fallen. Nevertheless, implementation of WSI remains a difficult prospect for many institutions, especially those with stakeholders unfamiliar with the technologies necessary to implement a system or who cannot effectively communicate to executive leadership and sponsors the benefits of a technology that may lack clear and immediate reimbursement opportunity.Objectives.-To present an overview of WSI technology-present and future-and to demonstrate several immediate applications of WSI that support pathology practice, medical education, research, and collaboration.Data Sources.-Peer-reviewed literature was reviewed by pathologists, scientists, and technologists who have practical knowledge of and experience with WSI.Conclusions.-Implementation of WSI is a multifaceted and inherently multidisciplinary endeavor requiring contributions from pathologists, technologists, and executive leadership. Improved understanding of the current challenges to implementation, as well as the benefits and successes of the technology, can help prospective users identify the best path for success.