Endothelin and the Cardiovascular System: The Long Journey and Where We Are Going.
Endothelin and the Cardiovascular System: The Long Journey and Where We Are Going.
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DOI：
10.3390/biology11050759
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发表时间：
2022-05-16
期刊：
影响因子：
4.2
通讯作者：
Emoto, Noriaki
中科院分区：
文献类型：
--
作者：
Haryono, Andreas;Ramadhiani, Risa;Ryanto, Gusty Rizky Teguh;Emoto, Noriaki
关键词：
本文综述了内皮素及其相关分子的基本功能，包括其受体和酶。此外，我们还讨论了内皮素在几种心血管疾病中的重要作用，内皮素途径靶向的相关临床证据，以及未来内皮素靶向治疗的范围。我们重点介绍了内皮素受体拮抗剂目前的应用和未来治疗方案的发展进展，从而提供了多年来内皮素研究的概述及其未来的范围。30多年前，内皮素作为一种有效的血管收缩药首次被发现。在接下来的几年里，人们鉴定了三种异构体、两种典型受体和两种转换酶，并通过大量的临床前和临床研究阐明了它们的基本功能。多年来，内皮素系统被发现在几种心血管疾病的发病机制中起关键作用，包括高血压、肺动脉高压、心力衰竭和冠状动脉疾病。本文就内皮素及其在心血管疾病中的作用作一综述。此外，我们还讨论了内皮素靶向疗法，如内皮素受体拮抗剂，如何被用于治疗心血管疾病，并取得了不同程度的成功。最后，我们提供了未来心血管疾病的内皮素靶向治疗选择的一瞥。
In this review, we describe the basic functions of endothelin and related molecules, including their receptors and enzymes. Furthermore, we discuss the important role of endothelin in several cardiovascular diseases, the relevant clinical evidence for targeting the endothelin pathway, and the scope of endothelin-targeting treatments in the future. We highlight the present uses of endothelin receptor antagonists and the advancements in the development of future treatment options, thereby providing an overview of endothelin research over the years and its future scope. Endothelin was first discovered more than 30 years ago as a potent vasoconstrictor. In subsequent years, three isoforms, two canonical receptors, and two converting enzymes were identified, and their basic functions were elucidated by numerous preclinical and clinical studies. Over the years, the endothelin system has been found to be critical in the pathogenesis of several cardiovascular diseases, including hypertension, pulmonary arterial hypertension, heart failure, and coronary artery disease. In this review, we summarize the current knowledge on endothelin and its role in cardiovascular diseases. Furthermore, we discuss how endothelin-targeting therapies, such as endothelin receptor antagonists, have been employed to treat cardiovascular diseases with varying degrees of success. Lastly, we provide a glimpse of what could be in store for endothelin-targeting treatment options for cardiovascular diseases in the future.
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影响因子：
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