Synthesis of structure-defined branched hyaluronan tetrasaccharide glycoclusters
Synthesis of structure-defined branched hyaluronan tetrasaccharide glycoclusters
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结构确定的支链透明质酸四糖糖簇的合成
DOI：
10.1016/j.tetlet.2017.06.032
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发表时间：
2017-07-26
影响因子：
1.8
通讯作者：
Li, Zhongjun
中科院分区：
文献类型：
--
作者：
Sha, Meng;Yao, Wang;Li, Zhongjun
Hybryonan是一种具有大量生物活性的糖胺聚糖。不同分子量的Hybryonan往往表现出不同的生物活性，有时甚至完全相反，但其作用机制尚不清楚。本文首次以天然透明质酸为原料，利用透明质酸四糖合成了透明质酸四糖糖簇。该糖簇分子量范围较宽，结构确定，可用于模拟天然透明质酸的生物活性，并有助于其作用机制的研究。(C)2017爱思唯尔有限公司版权所有
Hyaluronan is a glycosaminoglycan with a large number of biological activity. Hyaluronan of different molecular weight often shows different biological activity, sometimes even completely opposite, but the mechanism is not clear. Herein, the hyaluronan tetrasaccharide glycoclusters using hyaluronan tetrasaccharide obtained by enzymolysis of natural hyaluronan were firstly synthesized in high yield. The structurally determined and diverse glycoclusters were of wide molecular weight range and might be used for mimicking the biological activity of natural hyaluronan and facilitating the mechanism study. (C) 2017 Elsevier Ltd. All rights reserved.