SINGLE-CELL RESPONSES IN STRIATE CORTEX OF KITTENS DEPRIVED OF VISION IN 1 EYE
SINGLE-CELL RESPONSES IN STRIATE CORTEX OF KITTENS DEPRIVED OF VISION IN 1 EYE
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DOI：
10.1152/jn.1963.26.6.1003
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发表时间：
1963-01-01
影响因子：
2.5
通讯作者：
HUBEL, DH
中科院分区：
文献类型：
--
作者：
WIESEL, TN;HUBEL, DH
单个单位的记录是从小猫的纹状皮层，其中一只眼睛已经被剥夺了视觉从出生或随后，并在不同的时间段。出生后被剥夺2-3个月的小猫在被剥夺的眼睛中表现出严重的视力缺陷。从出生起就被剥夺了一只眼睛的眼睑或用半透明的接触性遮光器覆盖角膜的小猫，绝大多数皮层细胞被积极地从正常的眼睛中驱逐出来，具有正常的感受野。另一方面，在84个细胞中，只有一个细胞受到剥夺眼的影响，并且在其中两只眼睛的感受野是异常的。在小猫的视觉经验之前，单眼剥夺降低了生理缺陷的严重程度，而三个月的剥夺在成年猫的眼睑关闭没有检测到的生理异常。它的结论是单眼剥夺小猫可以导致无反应的皮层细胞刺激的剥夺眼睛，和缺陷是最严重的动物从出生开始被剥夺。
Single-unit recordings were made from striate cortex of kittens in which one eye had been deprived of vision either from birth or subsequently, and for various periods of time. Kittens deprived from birth for 2-3 months showed profoundly defective vision in the deprived eye. In kittens deprived from birth by suturing the lids of one eye or by covering the cornea with a translucent contact occluder, the great majority of cortical cells were actively driven from the normal eye, with normal receptive fields. On the other hand only one cell out of 84 was at all influenced by the deprived eye, and in it the receptive fields in the two eyes were abnormal. In kittens visual experience prior to monocular deprivation reduced the severity of the physiological defects, while three months of deprivation by lid closure in an adult cat produced no detectable physiological abnormality. It is concluded that monocular deprivation in kittens can lead to unresponsiveness of cortical cells to stimulation of the deprived eye, and that the defect is most severe in animals deprived from birth.