Age-related distribution of vertebral bone-marrow diffusivity
Age-related distribution of vertebral bone-marrow diffusivity
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DOI：
10.1016/j.ejrad.2012.03.033
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发表时间：
2012-12-01
影响因子：
3.3
通讯作者：
Habermann, Christian R.
中科院分区：
文献类型：
--
作者：
Herrmann, Jochen;Krstin, Nina;Habermann, Christian R.
目的：通过测量表观弥散系数(ADC)值来确定腰椎骨髓弥散率随年龄的变化。材料和方法：当地伦理委员会批准了这项研究，并获得书面知情同意。研究组88人，包括75名健康志愿者和13名患者(女性48人，男性40人；平均年龄36岁，范围0-84岁)。儿科病例来自患者。采用平面扩散加权成像，b值分别为50、400、800 S/mm(2)。计算并测量腰椎第1、2椎体的ADC值。结果：腰椎骨髓ADC值与年龄呈显著负相关(Rho=-0.398，p=0.001)。0~29岁组(平均18.0岁，n=42)和30~88岁组(平均51.6岁，n=46)的平均ADC值(x 10(-3)mm(2)/S)分别为0.54±0.07和0.47±0.08(P<；0.001，t检验)。结论：腰椎骨髓ADC值随年龄增长呈线性下降，反映了骨髓转化过程中细胞成分的逐渐变化。(C)2012爱思唯尔爱尔兰有限公司。保留所有权利。
Purpose: To determine age-related diffusivity changes of the lumbar bone marrow by measurement of apparent diffusion coefficient (ADC) values.Materials and methods: The local ethics committee approved this study and written informed consent was obtained. The study group comprised 88 individuals including 75 healthy volunteers and 13 patients (48 female, 40 male; mean age 36 years, range 0-84 years). The pediatric cases were recruited from patients. Echo-planar diffusion weighted imaging (DWI) was performed with b-values of 50, 400 and 800 s/mm(2). ADC-values were calculated and measured in the 1st and 2nd vertebral body of the lumbar spine. Correlation between age and ADC-values was analyzed with Spearman's rho test.Results: The ADC values of the vertebral bone marrow of the lumbar spine showed a significant negative correlation with age (rho = -0.398, p = 0.001). The mean ADC values (x 10(-3) mm(2)/s) in the age groups 0-29 years (mean age 18.0 years, n = 42) and 30-88 years (mean age 51.6 years, n = 46) were 0.54 +/- 0.07 and 0.47 +/- 0.08, respectively (p < 0.001, T-test). No significant differences were found between children and young adults.Conclusion: Bone marrow ADC values of the lumbar spine show a linear decrease with growing age and thereby reflect the gradual changes of cell composition occurring during marrow conversion. (C) 2012 Elsevier Ireland Ltd. All rights reserved.