Selective breeding for differential aggression in mice provides evidence for heterochrony in social behaviours
Selective breeding for differential aggression in mice provides evidence for heterochrony in social behaviours
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小鼠差异攻击性的选择性育种为社会行为异时性提供了证据
DOI：
10.1006/anbe.2000.1700
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发表时间：
2001
期刊：
影响因子：
2.5
通讯作者：
R. Cairns
中科院分区：
文献类型：
--
作者：
J. Gariépy;Daniel J. Bauer;R. Cairns
摘要本研究验证了一个假设，即小鼠的选择性繁殖对不同的攻击性产生了社会发展的异时变化。预计这些变化将采取攻击和冻结在低位线进行性幼化的形式。鉴于选择性繁殖的影响是单向的，预计高攻击性动物的发育轨迹不会改变。这些假设进行了测试，使用横截面（代S1，S4和S13）和纵向评估（S4和S13）的攻击和冻结行为在两个线。这些受试者被隔离饲养，并在28-30、37、42-45、72和180-280天的年龄进行二元测试（10分钟）。这种设计使我们能够（1）比较两个品系世代的发育速率，（2）确定在选择育种过程中经验对发育的影响是否发生变化，（3）评估在横向评估中获得的异时性变化信息与纵向评估相结合时是否得到保留。线，代，经验及其相互作用对发育功能的主要影响估计使用分层线性建模程序。幼态持续假说支持的攻击行为，无论是在横断面研究，并结合纵向调查。在这两项研究中也获得了冻结反应的paedomorphosis的证据。复制是可能的，因为经验对发展的影响不会随着世代而改变。这项研究表明，异时性变化可以通过实验操作，并在几代人中系统地绘制出来。我们的研究结果还表明，异时性变化可能有其起源的可塑性的表观遗传过程。
Abstract This research tested the hypothesis that selective breeding for differential aggression in mice produces heterochronic changes in social development. These changes were expected to take the form of a progressive neotenization of attack and freezing in the low line. Given that the effects of selective breeding were unidirectional, developmental trajectories were not expected to change among high-aggression animals. These hypotheses were tested using cross-sectional (generations S 1 , S 4 and S 13 ) and longitudinal evaluations (S 4 and S 13 ) of attack and freezing behaviours in the two lines. The subjects were reared in isolation and observed in a dyadic test (10 min) at the ages of 28–30, 37, 42–45, 72 and 180–280 days. This design permitted us to (1) compare developmental rates in the two lines over generations, (2) determine whether the effects of experience on development changed during the course of selective breeding, and (3) assess whether information on heterochronic changes obtained in a cross-sectional evaluation were preserved when combined to a longitudinal one. Main effects of line, generation, experience and their interactions on developmental functions were estimated using hierarchical linear modelling procedures. The neoteny hypothesis was supported for attack behaviours, both in cross-sectional studies and in combination with longitudinal investigations. Evidence for a paedomorphosis of the freezing response was also obtained in both studies. Replication was possible because experiential effects on development did not change over generations. This research demonstrated that heterochronic changes can be experimentally manipulated and mapped out systematically over generations. Our findings also suggested that heterochronic changes may have their origin in the plasticity of the epigenetic process.