Genetic variations and forensic characteristics of Han Chinese population residing in the Pearl River Delta revealed by 23 autosomal STRs
Genetic variations and forensic characteristics of Han Chinese population residing in the Pearl River Delta revealed by 23 autosomal STRs
复制标题
23条常染色体STR揭示珠江三角洲汉族人群遗传变异及法医学特征
DOI：
10.1007/s11033-018-4264-y
复制
发表时间：
2018-10-01
影响因子：
2.8
通讯作者：
Hou, Yiping
中科院分区：
文献类型：
--
作者：
He, Guanglin;Wang, Zheng;Hou, Yiping
珠江三角洲，素有中国“南大门”之称，毗邻港澳，与东南亚地区隔海相望。本研究对居住在珠江三角洲地区的4325名汉族个体进行了23个常染色体STR(扩增的CODIS核心基因座加上D6S1043、五角体D和五角体E)的基因分型。未观察到Bonferroni校正后偏离Hardy-Weinberg平衡的证据。综合匹配率为1.7829×10(-28)，综合排斥力为0.9999999996。其次，通过结构、MDS、主成分分析和邻接树等方法对不同种族、语言和地理分布的人群(基于相同的23个常染色体STR的11个中国人群、基于19个常染色体STR的等位基因频率分布的46个中国全国人群和基于20个常染色体STR的51个世界人群)进行了群体比较。前两个常染色体微卫星数据显示了中国各民族在民族语言边界(突厥语、藏缅语和汉语)和地理划分(北汉和南汉)上的遗传异质性。基于20个常染色体STR的全球群体遗传关系研究结果表明，在种族和地理位置相近的群体中存在遗传亲缘关系。
Pearl River Delta, known as the Chinese "South Gate", locates adjacent to Hong Kong and Macao, and across the sea from the Southeast Asian region. Herein, 4325 unrelated Han Chinese individuals residing in the Pearl River Delta region were recruited and genotyped with 23 autosomal STRs (the expanded CODIS core loci plus D6S1043, Penta D and Penta E). No evidence of deviation from Hardy-Weinberg equilibrium after Bonferroni correction was observed. The combined match probability and combined power of exclusion were 1.7829 x 10(-28) and 0.9999999996, respectively. Next, population comparisons among ethnically, linguistically, and geographically diverse populations (11 Chinese populations based on genotypes of same 23 autosomal STRs, 46 Chinese nationwide populations based on allele frequency distributions of 19 autosomal STRs and 51 worldwide populations on the basis of 20 autosomal STRs) were performed via Structure, MDS, PCA and neighbor-joining tree. Genetic heterogeneities among Chinese nationalities along ethno-linguistic boundaries (Turkic-speaking, Tibeto-Burman-speaking, and Chinese-speaking populations) and geographic divisions (North-Han and South-Han) have been illustrated by first two autosomal microsatellite datasets. The results from worldwide population genetic relationship exploration based on 20 autosomal STRs demonstrated that genetic affinity has existed within ethnical and geographical close populations.