Metabolism in tumor-associated macrophages.
Metabolism in tumor-associated macrophages.
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DOI：
10.1016/bs.ircmb.2022.01.004
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发表时间：
2022
影响因子：
--
通讯作者：
Ruffell, Brian
中科院分区：
文献类型：
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作者：
Li, Jie;DeNicola, Gina M;Ruffell, Brian
巨噬细胞在功能上适应一系列不同的信号，这一过程对于它们在维持或恢复组织内稳态方面的作用至关重要。这一过程延伸到癌症，巨噬细胞对一系列炎症和代谢信号做出反应，这些信号指导着一种不适应的愈合反应。肿瘤相关巨噬细胞(TAMs)改变了葡萄糖、氨基酸和脂类的代谢特征，干扰这种代谢变化会削弱巨噬细胞促进肿瘤生长、转移和创造免疫抑制微环境的能力。在这里，我们将回顾TAMS中代谢物和代谢途径的变化，并将其与细胞的表型和功能特性联系起来。我们还将讨论目前针对代谢作为癌症治疗干预的策略。
Macrophages functionally adapt to a diverse set of signals, a process that is critical for their role in maintaining or restoring tissue homeostasis. This process extends to cancer, where macrophages respond to a series of inflammatory and metabolic cues that direct a maladaptive healing response. Tumor-associated macrophages (TAMs) have altered glucose, amino acid, and lipid metabolic profiles, and interfering with this metabolic shift can blunt the ability of macrophages to promote tumor growth, metastasis, and the creation of an immunosuppressive microenvironment. Here we will review changes in metabolites and metabolic pathways in TAMs and link these with the phenotypic and functional properties of the cells. We will also discuss current strategies targeting TAM metabolism as a therapeutic intervention in cancer.