Calmodulin-activated bacterial adenylate cyclases as virulence factors.
Calmodulin-activated bacterial adenylate cyclases as virulence factors.
复制标题
DOI：
10.1016/0966-842x(93)90089-a
复制
发表时间：
1993-08-01
影响因子：
15.9
通讯作者：
Ullmann, A
中科院分区：
文献类型：
--
作者：
Mock, M;Ullmann, A
百日咳杆菌和炭疽芽孢杆菌各自产生一种毒力相关的、依赖于钙调素的腺苷酸环化酶毒素，这种毒素在真核细胞中产生更高水平的环AMP。这两种蛋白质在其催化结构域上具有序列相似性。其余区域显示出不同的结构和功能组织，这解释了两种毒素与靶细胞的相互作用以及由此产生的疾病症状的差异。
Bordetella pertussis and Bacillus anthracis each produce a virulence-associated, calmodulin-dependent adenylate cyclase toxin, which generates increased levels of cyclic AMP in eukaryotic cells. The two proteins share sequence similarities in their catalytic domains. The remaining regions display different structural and functional organizations that account for the differences both in interaction of the two toxins with target cells and in the resulting disease symptoms.