Gastric axial forces in experimentally delayed and accelerated gastric emptying.
Gastric axial forces in experimentally delayed and accelerated gastric emptying.
复制标题
胃轴向力在实验上延迟和加速胃排空。
DOI：
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发表时间：
1993
影响因子：
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通讯作者：
A. Zinsmeister
中科院分区：
文献类型：
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作者：
C. Prather;Michael Camilleri;G. Thomforde;Lee A. Forstrom;A. Zinsmeister
本研究的目的是评估改变轴向力和胃排空的固体实验抑制或刺激胃轴向力的十二指肠内脂质或静脉注射红霉素，分别之间的关系。在15名健康志愿者中，我们同时测量胃排空的固体造影，胃十二指肠动力测压，和力沿着纵向轴的远端胃的轴向力传感器。当25%的放射性标记物从胃中排空时，受试者（每组n = 5）接受生理盐水（对照）、十二指肠内脂质或静脉注射红霉素。试验期包括输注期（10 min）和随后的30 min。与对照组相比，脂质显著降低，红霉素增加轴向力（脂质：中位数0.6 N [0-1.4四分位数间距（IQR）];红霉素：中位数18.2 N（16.5-20.5 IQR）;对照组：中位数4.7 N（3.9-5.2 IQR）; P < 0.01）。同样，胃窦相位压力活动相对于对照不同。胃轴向力与胃排空显著相关（斯皮尔曼等级相关= 0.86; P < 0.01）。这些数据与轴向力影响固体胃排空的假设一致，并表明轴向力的测量提供了固体排空期间整体胃推进的评估。
The aim of this study was to assess the relationship between altered axial forces and gastric emptying of solids by experimentally inhibiting or stimulating gastric axial forces by intraduodenal lipid or intravenous erythromycin, respectively. In 15 healthy volunteers, we simultaneously measured gastric emptying of solids by scintigraphy, gastroduodenal motility by manometry, and forces along the longitudinal axis of the distal stomach by an axial force transducer. When 25% of the radiolabel had emptied from the stomach, subjects (n = 5 in each group) received normal saline (controls), intraduodenal lipid, or intravenous erythromycin. The test period consisted of the infusion period (10 min) and the subsequent 30 min. Lipid significantly reduced and erythromycin increased axial forces compared with control (lipid: median 0.6 N [0-1.4 interquartile range (IQR)]; erythromycin: median 18.2 N (16.5-20.5 IQR); control: median 4.7 N (3.9-5.2 IQR); P < 0.01). Similarly, antral phasic pressure activities were different relative to control. Gastric axial forces correlated significantly with gastric emptying (Spearman rank correlation = 0.86; P < 0.01). These data are consistent with the hypothesis that axial forces affect gastric emptying of solids and suggest that measurement of axial forces provides an assessment of overall gastric propulsion during the emptying of solids.