Divergent allele advantage at MHC-DRB through direct and maternal genotypic effects and its consequences for allele pool composition and mating
Divergent allele advantage at MHC-DRB through direct and maternal genotypic effects and its consequences for allele pool composition and mating
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DOI：
10.1098/rspb.2013.0714
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发表时间：
2013-07-07
影响因子：
4.7
通讯作者：
Wolf, Jochen B. W.
中科院分区：
文献类型：
--
作者：
Lenz, Tobias L.;Mueller, Birte;Wolf, Jochen B. W.
目前仍有争议的是，在自然群体中主要的个体适应性差异是否可以归因于全基因组效应或突出的功能重要性，如主要组织相容性复合体（MHC）的特定位点。在一个长期监测项目的加拉帕戈斯海狮（Zalophus wollebaeki），我们收集了全面的健身和交配数据，共506人。控制全基因组近亲繁殖，我们发现MHC基因座和几乎所有的健身性状之间有很强的关联。这种效应主要归因于MHC序列的差异，并可分解为自身和母体基因型的贡献。因此，人口似乎已经演变成一个池的高度分歧等位基因传达近最佳的MHC分歧，即使是随机交配。我们的结果表明，单个基因座可以显着促进野生环境中的适应性，并为“不同等位基因优势”假说提供了确凿的证据，这是一种具有有趣进化意义的特殊平衡选择形式。
It is still debated whether main individual fitness differences in natural populations can be attributed to genome-wide effects or to particular loci of outstanding functional importance such as the major histocompatibility complex (MHC). In a long-term monitoring project on Galapagos sea lions (Zalophus wollebaeki), we collected comprehensive fitness and mating data for a total of 506 individuals. Controlling for genome-wide inbreeding, we find strong associations between the MHC locus and nearly all fitness traits. The effect was mainly attributable to MHC sequence divergence and could be decomposed into contributions of own and maternal genotypes. In consequence, the population seems to have evolved a pool of highly divergent alleles conveying near-optimal MHC divergence even by random mating. Our results demonstrate that a single locus can significantly contribute to fitness in the wild and provide conclusive evidence for the 'divergent allele advantage' hypothesis, a special form of balancing selection with interesting evolutionary implications.