The quinolones: Past, present, and future
The quinolones: Past, present, and future
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DOI：
10.1086/428051
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发表时间：
2005-07-15
影响因子：
11.8
通讯作者：
Andriole, VT
中科院分区：
文献类型：
--
作者：
Andriole, VT
自 140 年前发现以来，喹诺酮类抗菌剂引起了人们极大的兴趣。我们对喹诺酮类药物对抗病原菌作用的分子机制、在这些生物体中诱导喹诺酮类药物耐药性以及每种喹诺酮类化合物在治疗患者中诱导毒性的潜力的理解取得了实质性进展。在这里，我们回顾了这些关键发现；详细描述了监管机构批准的现有适应症，并对喹诺酮类药物在治疗患者中引起的不良事件进行了评论；人们对喹诺酮类药物的未来进行了猜测，尽管它们的未来很难预测，因为许多因素可能会影响它们的临床用途。然而，细菌对喹诺酮类药物耐药性的出现是决定这些药物未来临床有效性的一个主要因素，因此深入研究预防或减少对喹诺酮类药物耐药性的机制对其未来至关重要。
The quinolone class of antimicrobial agents has generated considerable interest since its discovery 140 years ago. Substantial progress has been made in our understanding of the molecular mechanisms of the action of quinolones against pathogenic bacteria, the induction of resistance to quinolones in these organisms, and the potential of each quinolone compound to induce toxicity in treated patients. Here, these key discoveries are reviewed; the present indications approved by regulatory agencies are described in detail, with comments on adverse events caused by quinolones in treated patients; and speculation about the future of the quinolones is proffered, even though their future is difficult to predict, because many factors may affect their clinical usefulness. However, the emergence of bacterial resistance to the quinolones is a major factor that will determine the future clinical effectiveness of these agents, so that intense investigation of mechanisms to either prevent or curtail resistance to quinolones is of prime importance to their future.