Parenteral vs. inhaled atropine: density dependence of maximal expiratory flow.
Parenteral vs. inhaled atropine: density dependence of maximal expiratory flow.
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肠胃外与吸入阿托品：最大呼气流量的密度依赖性。
DOI：
10.1152/jappl.1982.53.2.392
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
IngramJr,RH
中科院分区：
文献类型：
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作者：
Weiss,JW;McFaddenJr,ER;IngramJr,RH
使用强制肺活量操作，我们测量了正常非吸烟受试者的最大呼气流量（Vmax）和肺的静态弹性后坐力[Pst(L)]，这些受试者在吸入和静脉注射硫酸阿托品之前和之后呼吸空气并经过80%氦-20%氧的洗涤。两种途径对Vmaxair的影响均相同，但对Vmax的密度依赖性（DD = VmaxHeO2与Vmaxair的比值）和Pst(L)的影响不同。在30%肺活量时，吸入药物后DD由平均1.47降至1.32 （P < 0.01，配对t检验），而非肠外给药后DD无变化[1.44 vs. 1.48 (P > 0.2)]。吸入后Pst(L)没有变化，但经肠外给药后Pst(L)明显降低。我们解释这些发现表明，吸入途径和肠外剂量后更均匀的扩张主要是大气道效应。这些结果与β -肾上腺素能扩张术相反，后者无论给药途径如何，都以小气道效应为主。
Using forced vital capacity maneuvers, we measured maximal expiratory flow rates (Vmax) and static elastic recoil pressures of the lung [Pst(L)] using quasi-static maneuvers in normal nonsmoking human subjects who were breathing air and after a washing of 80% helium-20% oxygen before and after both inhaled and intravenously administered atropine sulfate. By both routes there were equivalent increases in Vmaxair but different effects on density dependence (DD) of Vmax (DD = ratio of VmaxHeO2 to Vmaxair) and on Pst(L). At 30% of vital capacity, DD decreased from an average of 1.47 to 1.32 (P less than 0.01, paired t test) after inhaled drug and did not change after parenteral administration [1.44 vs. 1.48 (P greater than 0.2)]. After inhalation Pst(L) did not change, but after parenteral administration Pst(L) significantly decreased. We interpret these findings to indicate a predominantly large-airway effect with the inhalation route and a more uniform dilatation after the parenteral dose. These results contrast with beta-adrenergic dilatation following which small-airway effects predominate regardless of route of administration.