Temperature measurement on tissue surface during laser irradiation
Temperature measurement on tissue surface during laser irradiation
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DOI：
10.1007/s11517-007-0251-5
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发表时间：
2008-02-01
影响因子：
3.2
通讯作者：
Chen, Wei R.
中科院分区：
文献类型：
--
作者：
Gnyawali, Surya C.;Chen, Yicho;Chen, Wei R.
治疗部位上的组织表面温度分布可以用作光热疗法的有效性的指标。本研究采用红外热成像技术和理论模拟相结合的方法，研究了激光辐照凝胶体模和动物肿瘤时的表面温度分布。选择性光热相互作用，试图通过使用瘤内吲哚菁绿色增强和辐射，通过近红外激光。免疫佐剂也用于增强肿瘤治疗期间的免疫应答。采用蒙特卡罗方法模拟组织对光的吸收，有限差分方法模拟组织中的热扩散，模拟了选择性激光光热作用过程中的温度分布。在激光处理过程中，使用红外相机捕获热图像，并确定表面温度。我们的研究结果表明，理论和实验结果是一致的，照射组织的表面温度可以控制适当的染料和辅助增强。这些结果可用于控制激光肿瘤治疗参数和优化治疗结果。更重要的是，当与免疫疗法一起使用作为免疫反应的前体时，选择性光热治疗可以由肿瘤中和表面上的组织温度分布来指导。
Tissue surface temperature distribution on the treatment site can serve as an indicator for the effectiveness of a photothermal therapy. In this study, both infrared thermography and theoretical simulation were used to determine the surface temperature distribution during laser irradiation of both gel phantom and animal tumors. Selective photothermal interaction was attempted by using intratumoral indocyanine green enhancement and irradiation via a near-infrared laser. An immunoadjuvant was also used to enhance immunological responses during tumor treatment. Monte Carlo method for tissue absorption of light and finite difference method for heat diffusion in tissue were used to simulate the temperature distribution during the selective laser photothermal interaction. An infrared camera was used to capture the thermal images during the laser treatment and the surface temperature was determined. Our findings show that the theoretical and experimental results are in good agreement and that the surface temperature of irradiated tissue can be controlled with appropriate dye and adjuvant enhancement. These results can be used to control the laser tumor treatment parameters and to optimize the treatment outcome. More importantly, when used with immunotherapy as a precursor of immunological responses, the selective photothermal treatment can be guided by the tissue temperature profiles both in the tumor and on the surface.