Tenascins
Tenascins
复制标题
DOI：
10.1016/j.biocel.2003.12.002
复制
发表时间：
2004-06-01
影响因子：
4
通讯作者：
Chiquet-Ehrismann, R
中科院分区：
文献类型：
--
作者：
Chiquet-Ehrismann, R
腱生蛋白是一个大的多聚体细胞外基质（ECM）蛋白家族。脊椎动物表达存在于其结缔组织中的四种腱生蛋白，称为腱生蛋白-C、-R、-X和-W。每种腱生蛋白都有特定的表达模式。与许多其他ECM蛋白相反，腱生蛋白仅促进弱的细胞粘附并且不激活细胞铺展。它们已被分类为抗粘附、粘附调节或甚至排斥性ECM蛋白。腱生蛋白-C和腱生蛋白-R缺陷型小鼠在神经系统中显示出异常，此外，腱生蛋白-C缺陷型小鼠在几个再生过程中具有缺陷。缺乏腱生蛋白-X的小鼠显示出超弹性皮肤，就像在腱生蛋白-X基因中有突变的埃勒斯·丹洛斯患者一样。由于生肿蛋白-C在肿瘤基质中高度过表达，因此针对生肿蛋白-C的抗体已用于肿瘤诊断和治疗。由于已知腱生蛋白影响细胞形状、迁移和生长，因此它们代表用于包含在人工生物工程组织植入物中的良好候选分子。(C)2004爱思唯尔有限公司保留所有权利。
Tenascins are a family of large multimeric extracellular matrix (ECM) proteins. Vertebrates express four tenascins termed tenascin-C, -R, -X and -W present in their connective tissues. Each tenascin has a specific expression pattern. To the contrary of many other ECM proteins, tenascins promote only weak cell adhesion and do not activate cell spreading. They have been classified as anti-adhesive, adhesion-modulating or even repellent ECM proteins. Tenascin-C and tenascin-R deficient mice show abnormalities in the nervous system and tenascin-C deficient mice, in addition, have defects in several regenerative processes. Mice lacking tenascin-X display hyperelastic skin much like Ehlers Danlos patients with mutations in their tenascin-X gene. Since tenascin-C is highly overexpressed in tumor stroma antibodies against tenascin-C have been used in tumor diagnosis and therapy. Since tenascins are known to influence cell shape, migration and growth they represent good candidate molecules for inclusion in artificial bioengineered tissue implants. (C) 2004 Elsevier Ltd. All rights reserved.