MR atlas of the baboon brain for functional neuroimaging
MR atlas of the baboon brain for functional neuroimaging
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DOI：
10.1016/s0361-9230(02)00810-9
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发表时间：
2002-08-15
影响因子：
3.8
通讯作者：
Price, JC
中科院分区：
文献类型：
--
作者：
Greer, PJ;Villemagne, VL;Price, JC
功能图像数据的数学共配准（例如，正电子发射断层扫描（PET）与解剖磁共振（MR）成像数据的比较允许功能与解剖结构之间的客观关联。狒狒经常被用作功能性神经影像学研究的非人灵长类动物模型。在这项工作中，狒狒大脑的数字MR为基础的高分辨率图集生成和PET评估。该图谱由6个SPGR-MR数据集（以正中矢状线为中心，AC-PC方向）生成，这些数据集被转换到一个代表性MR的空间中，平均并重新采样到PET空间中。通过比较血流和多巴胺受体和5-羟色胺转运蛋白结合测量值来评价图谱，所述结合测量值使用在每个单独的共同配准的MR（ROI（i））上生成的感兴趣区域（ROI）和图谱定义的ROI模板（ROIATLAS）确定。应用于所有数据的常见ROI包括额叶皮质、颞叶皮质、丘脑、尾状核、壳核和小脑。所有放射性示踪剂的ROIi和ROIATLAS数据之间存在高度相关性（r（2）> 0.87）（每只狒狒ROI之间的线性回归）。放射性示踪剂的平均回归斜率值范围为0.95至1.02。最后，使用的地图集的统计参数映射（SPM）的[O-15]水数据产生了良好的协议与以前的ROIi的结果。总体而言，基于MR的数字图谱允许自动配准，在一系列PET研究中证明是有用的，并且可以通过互联网以电子方式访问。(C)2002年爱思唯尔科学公司All rights reserved.
Mathematical co-registration of functional image data (e.g., positron emission tomography, PET) to anatomical magnetic resonance (MR) imaging data allows for objective Associations between function and anatomy. Baboons are often used as non-human primate models for functional neuroimaging studies. In this work, a digital MR-based high-resolution atlas of the baboon brain was generated and evaluated for PET. The atlas was generated from six SPGR-MR datasets (centered at mid-sagittal line, AC-PC orientation) that were transformed into the space of one representative MR, averaged and resampled into PET space. The atlas was evaluated by comparing blood flow and dopamine receptor and serotonin transporter binding measures determined using regions-of-interest (ROIs) generated on each individual co-registered MR (ROl(i)) and the atlas-defined ROI template (ROIATLAS). Common ROIs applied to all data included frontal cortex, temporal cortex, thalamus, caudate, putamen and cerebellum. High correlations (r(2) > 0.87) were found between the ROIi and ROIATLAS data for all radiotracers (linear regression across ROIs for each baboon). The average regression slope values ranged from 0.95 to 1.02 across radiotracers. Lastly, use of the atlas for statistical parametric mapping (SPM) of [O-15]water data yielded good agreement with previous ROIi results. Overall, the digital MR-based atlas allowed for automatic co-registration, proved useful across a range of PET Studies, and is accessible electronically via the Internet. (C) 2002 Elsevier Science Inc. All rights reserved.