OPTICAL TIME-OF-FLIGHT AND ABSORBENCY IMAGING OF BIOLOGIC MEDIA
OPTICAL TIME-OF-FLIGHT AND ABSORBENCY IMAGING OF BIOLOGIC MEDIA
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DOI：
10.1126/science.8451643
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发表时间：
1993-03-05
期刊：
影响因子：
56.9
通讯作者：
STEVENSON, DK
中科院分区：
文献类型：
--
作者：
BENARON, DA;STEVENSON, DK
活体内部的光成像可能有助于诊断和治疗一些临床问题，包括早期发现肿瘤和缺氧性脑损伤。现有的皮秒飞行时间和吸收(TOFA)光学系统已被用于成像一个模型生物系统和一只大鼠。模型测量证实了具有高度光子散射的系统中的TOFA原理；老鼠图像是由固定比例的早期到达的传输光子经历的可变时间延迟构建的，揭示了可识别的内部结构。基于光的定量测量和TOFA定位的组合可能在人体结构成像和空间化学计量学分析的连续、非侵入性监测中应用。
Imaging the interior of living bodies with light may assist in the diagnosis and treatment of a number of clinical problems, which include the early detection of tumors and hypoxic cerebral injury. An existing picosecond time-of-flight and absorbance (TOFA) optical system has been used to image a model biologic system and a rat. Model measurements confirmed TOFA principles in systems with a high degree of photon scattering; rat images, which were constructed from the variable time delays experienced by a fixed fraction of early-arriving transmitted photons, revealed identifiable internal structure. A combination of light-based quantitative measurement and TOFA localization may have applications in continuous, noninvasive monitoring for structural imaging and spatial chemometric analysis in humans.