Development and prospective application of quantitative 2-day stress-rest Tc-99m methoxy isobutyl isonitrile SPECT for the diagnosis of coronary artery disease.
Development and prospective application of quantitative 2-day stress-rest Tc-99m methoxy isobutyl isonitrile SPECT for the diagnosis of coronary artery disease.
复制标题
定量 2 天应激休息 Tc-99m 甲氧基异丁基异腈 SPECT 诊断冠状动脉疾病的开发和前瞻性应用。
DOI：
10.1016/0002-8703(90)90234-o
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发表时间：
1990
影响因子：
4.8
通讯作者：
D. Berman
中科院分区：
文献类型：
--
作者：
H. Kiat;H. Kiat;K. V. Train;K. V. Train;J. Maddahi;J. Maddahi;J. Corbett;J. Corbett;Ken Nichols;Ken Nichols;A. McGhie;A. Mcghie;M. Akers;M. Akers;J. Friedman;J. Friedman;L. Roy;L. Roy;D. Berman;D. Berman
使用两种不同的相机/计算机系统，在来自两个不同地点的61名患者的验证人群中评估了2天负荷/休息定量锝-99m（Tc-99 m）甲氧基异丁基异腈（Tc-sestamibi）单光子发射计算机断层扫描（SPECT）的临床诊断准确性。研究人群由53名导管插入患者组成，其中29名来自Cedars-Sinai医学中心（CSMC），24名来自德克萨斯大学西南医学中心（UTSMC），8名UTSMC患者的冠状动脉疾病检测前可能性<5%。解释采用了CSMC另外15名男性和8名女性的性别特异性正常限值，其显著冠状动脉疾病的可能性小于5%。CSMC的结果与UTSMC的结果相比，没有差异。检测冠状动脉疾病（≥50%狭窄）患者的总体灵敏度为94%（CSMC：92%，UTSMC：95%）。5例冠状动脉造影正常患者的总体特异性为80%（CSMC：67%，UTSMC：100%）。冠心病可能性低的患者的正常率为88%。血管敏感性为85%（CSMC：84%，UTSMC：85%），而血管特异性为71%（CSMC：72%，UTSMC：69%）。男性和女性人群之间的敏感性和特异性也没有显着差异。此外，与冠状动脉造影评估疾病程度（正常冠状动脉造影，单支或多支病变）的一致性为75%（kappa = 0.6 ± 0.1）。本研究表明，Tc-sestamibi SPECT定量分析是准确的检测和定位冠状动脉疾病。此外，CSMC定量方法被证明提供类似的诊断准确性时，应用于在不同的网站使用不同的相机/计算机系统采集的数据。
The clinical diagnostic accuracy of 2-day stress/rest quantitative Technetium-99m (Tc-99m) methoxy-isobutyl-isonitrile (Tc-sestamibi) single photon emission computerized tomography (SPECT) was assessed in a validation population of 61 patients from two different sites using two different camera/computer systems. The study population was made up of 53 catheterized patients, 29 from Cedars-Sinai Medical Center (CSMC) and 24 from the University of Texas Southwestern Medical Center (UTSMC), and eight UTSMC patients with a <5% pre-test likelihood of coronary artery disease. Interpretation employed gender-specific normal limits developed in an additional 15 men and 8 women at CSMC with less than a 5% likelihood of significant coronary artery disease. The results from CSMC compared with those from UTSMC were not different from each other. The overall sensitivity for detection of patients with coronary artery disease (≥50% stenosis) was 94% (CSMC: 92%, UTSMC: 95%). Overall specificity in the five patients with normal coronary arteriograms was 80% (CSMC: 67%, UTSMC: 100%). The normalcy rate in patients with a low likelihood of coronary artery disease was 88%. Vessel sensitivity was 85% (CSMC: 84%, UTSMC: 85%), while vessel specificity was 71% (CSMC: 72%, UTSMC: 69%). There was also no significant difference in the sensitivities and specificities between male and female populations. In addition, the agreement with coronary angiography for assessment of disease extent (normal coronary arteriogram, single or multivessei disease) was 75% (kappa = 0.6 ± 0.1). This study demonstrated that Tc-sestamibi SPECT by quantitative analysis is accurate for the detection and localization of coronary artery disease. Furthermore, the CSMC quantitative method was shown to provide similar diagnostic accuracy when applied to data acquired at a different site using a different camera/computer system.
DOI：
--
发表时间：
1988-12
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
R. Eisner;M. J. Tamas;K. Cloninger;D. Shonkoff;J. Oates;Anita M. Gober;D. Dunn;J. Malko;A. C
通讯作者：
R. Eisner;M. J. Tamas;K. Cloninger;D. Shonkoff;J. Oates;Anita M. Gober;D. Dunn;J. Malko;A. C