Serum Levels of Epidermal Growth Factor, Transforming Growth Factor, and c-erbB2 in Ovarian Cancer
Serum Levels of Epidermal Growth Factor, Transforming Growth Factor, and c-erbB2 in Ovarian Cancer
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DOI：
10.1097/igc.0b013e31825b7dcc
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发表时间：
2012-09-01
影响因子：
4.8
通讯作者：
Cift, Tayfur
中科院分区：
文献类型：
--
作者：
Balcan, Eray;Demirkiran, Fuat;Cift, Tayfur
目的：本研究旨在探讨血清表皮生长因子（EGF），转化生长因子α（TGF-α），c-erbB 2在卵巢癌患者的水平。材料和方法：在这项回顾性队列研究中，研究组和对照组分别由43名妇女与卵巢癌的预先诊断和43名健康妇女，分别。采集所有女性的血液样本，并通过EGF、TGF-α和c-erbB 2的酶联免疫吸附测定试剂盒进行研究。研究组术后确诊为卵巢癌，并与对照组进行比较。结果：研究组血清EGF、TGF-α、c-erbB 2水平均显著高于对照组（P <0.001），而对照组血清EGF、TGF-α、c-erbB 2水平均显著低于研究组（P < 0.001）。在卵巢癌的所有分期、分级和组织学类型中，血清EGF、TGF-α和c-erbB 2水平无差异。若以47.90 pg/mL为界值，EGF检测卵巢癌的敏感性为80%，特异性为65%。TGF-α的临界值为41，095.00 pg/mL，检测卵巢癌的灵敏度为90%，特异性为72%。结论：血清EGF、TGF-α和c-erbB 2水平可作为卵巢癌诊断的参考指标。
Objective: This study aimed to investigate serum levels of epidermal growth factor (EGF), transforming growth factor alpha (TGF-alpha), and c-erbB2 in patients with ovarian cancer.Materials and Methods: In this retrospective cohort study, the study and control groups were composed of 43 women with a prediagnosis of ovarian cancer and 43 healthy women, respectively. Blood samples from all women were obtained and studied by enzyme-linked immunosorbent assay kits for EGF, TGF-alpha, and c-erbB2. After surgery of the study group, ovarian cancer was confirmed and compared with control group. Stage, grade, and histological types were defined after histopathologic examination, and subgroups were constructed and compared.Results: Serum EGF, TGF-alpha, and c-erbB2 levels were significantly increased in study group compared with those in the control group (P < 0.001). There were no differences in serum levels of EGF, TGF-alpha, and c-erbB2 among all stages, grades, and histological types of ovarian cancer. If 47.90 pg/mL was selected as the cutoff value, EGF has an 80% sensitivity and a 65% specificity for detecting ovarian cancer. The cutoff value of 41,095.00 pg/mL for TGF-alpha has a 90% sensitivity and a 72% specificity for detecting ovarian cancer. The c-erbB2 level of 4.63 pg/mL as the cutoff value has an 83% sensitivity and a 76% specificity for predicting ovarian cancer.Conclusions: Serum levels of EGF, TGF-alpha, and c-erbB2 may be used for diagnosing ovarian cancer.