Artificial nucleic acid backbones and their applications in therapeutics, synthetic biology and biotechnology.
Artificial nucleic acid backbones and their applications in therapeutics, synthetic biology and biotechnology.
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DOI：
10.1042/etls20210169
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发表时间：
2021-11-12
影响因子：
3.8
通讯作者：
Brown T
中科院分区：
文献类型：
--
作者：
Epple S;El-Sagheer AH;Brown T
DNA或RNA骨架的修饰是治疗性寡核苷酸、合成生物学和生物技术领域的一项新兴技术。尽管据报道有过多的人造脊椎，但它们的巨大潜力并未得到充分利用。有限的合成可及性仍然是骨架修饰寡核苷酸广泛应用的主要瓶颈。因此，迫切需要各种容易获得的人工骨架和强有力的方法将其引入寡核苷酸，以充分利用其在治疗学、合成生物学和生物技术方面的潜力。
The modification of DNA or RNA backbones is an emerging technology for therapeutic oligonucleotides, synthetic biology and biotechnology. Despite a plethora of reported artificial backbones, their vast potential is not fully utilised. Limited synthetic accessibility remains a major bottleneck for the wider application of backbone-modified oligonucleotides. Thus, a variety of readily accessible artificial backbones and robust methods for their introduction into oligonucleotides are urgently needed to utilise their full potential in therapeutics, synthetic biology and biotechnology.