In vivo anti-cancer efficacy of magnetite nanocrystal-based system using locoregional hyperthermia combined with 5-fluorouracil chemotherapy
In vivo anti-cancer efficacy of magnetite nanocrystal-based system using locoregional hyperthermia combined with 5-fluorouracil chemotherapy
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DOI：
10.1016/j.biomaterials.2013.07.012
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发表时间：
2013-10-01
期刊：
影响因子：
14
通讯作者：
Yeh, Chen-Sheng
中科院分区：
文献类型：
--
作者：
Li, Tsung-Ju;Huang, Chih-Chia;Yeh, Chen-Sheng
我们提出了一种方法，用于同步热疗和热响应局部药物释放。该靶向探针具有磁铁矿铁（Fe3O4@PSMA）核和多核苷酸壳，其携带5-氟尿嘧啶（5-FU）和抗人表皮生长因子受体2（抗HER 2）抗体，用于癌细胞特异性靶向。靶向纳米晶体在肿瘤热疗中起着重要的作用，它可以传递外部传递的射频能量。然后局部热触发药物从寡核苷酸载体释放，因为它直接损伤肿瘤细胞。细胞活力测定和病理学检查表明，这种同步化在体外和体内模型中比单独的热疗或化疗更有效。在静脉注射纳米颗粒后，通过射频同步热疗和化疗实现了体内显著的肿瘤缓解。(C)2013爱思唯尔有限公司保留所有权利。
We present an approach for synchronizing hyperthermia and thermal-responsive local drug release. The targeting probe has a magnetite nanocrystal (Fe3O4@PSMA) core and a polynucleotide shell that carries 5-fluorouracil (5-FU) and anti-human epidermal growth factor receptor 2 (anti-HER2) antibody for cancer cell-specific targeting. The targeting nanocrystals play as an important role to relay the externally delivered radiofrequency energy for tumor hyperthermia. Locoregional heat then triggers a drug release from the oligonucleotide carrier as it directly damages tumor cells. Cell viability assays and pathological examinations show that this synchronization is significantly more efficacious in both in vitro and in vivo models than hyperthermia or chemotherapy alone. Prominent tumor remission in vivo was achieved through radiofrequency synchronization of hyperthermia and chemotherapy after the nanoparticle had been intravenously injected. (C) 2013 Elsevier Ltd. All rights reserved.