Bronchioloalveolar carcinoma: Clinical histopathologic, and radiologic findings
Bronchioloalveolar carcinoma: Clinical histopathologic, and radiologic findings
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DOI：
10.1148/radiographics.17.6.9397450
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发表时间：
1997-11-01
期刊：
影响因子：
5.5
通讯作者：
Primack, SL
中科院分区：
文献类型：
--
作者：
Lee, KS;Kim, Y;Primack, SL
细支气管肺泡癌的病理学特征是显示鳞状生长的肺部肿瘤。超过一半的细支气管肺泡癌患者没有症状。最常见的症状和体征是咳嗽、咳痰、气短、体重减轻、咯血和发烧，支气管漏不常见，是晚期表现。与粘液性细支气管肺泡癌相比，非粘液性细支气管肺泡癌往往更为局限性，并且支气管扩散的频率较低。细支气管肺泡癌在放射学上表现为单个结节、节段性或叶性实变或弥漫性结节。在计算机断层扫描 (CT) 中，单个结节形式表现为周围结节或局部毛玻璃状衰减，伴或不伴实变，通常与低衰减的气泡状区域和开放支气管征象相关。肺叶实变型可显示 CT 血管造影和开放支气管征象。弥漫性结节形式表现为多个结节或毛玻璃衰减或实变区域。单一结节形式比其他结节形式具有更好的预后，但在 2-(氟-18)氟-2-脱氧-D-葡萄糖正电子发射断层扫描中可能显示恶性肿瘤的假阴性结果。
Bronchioloalveolar carcinoma is characterized pathologically by a pulmonary neoplasm showing lepidic growth. More than half of all patients with bronchioloalveolar carcinoma are asymptomatic. The most frequent symptoms and signs are cough, sputum, shortness of breath, weight loss, hemoptysis, and fever, Bronchorrhea is unusual and a late manifestation. Nonmucinous bronchioloalveolar carcinoma tends to be more localized and has a lower frequency of bronchogenic spread than mucinous bronchioloalveolar carcinoma. Bronchioloalveolar carcinoma appears radiographically as a single nodule, segmental or lobar consolidation, or diffuse nodules. At computed tomography (CT), the single nodular form appears as a peripheral nodule or localized ground-glass attenuation with or without consolidation, frequently associated with bubblelike areas of low attenuation and open bronchus signs. The lobar consolidative form may demonstrate the CT angiogram and open bronchus signs. The diffuse nodular form appears as multiple nodules or areas of ground-glass attenuation or consolidation. The single nodular form has a better prognosis than the others but may show false-negative results for malignancy at 2-(fluorine-18) fluoro-2-deoxy-D-glucose positron emission tomography.