Regulation of T cell activation, anxiety, and male aggression by RGS2
Regulation of T cell activation, anxiety, and male aggression by RGS2
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DOI：
10.1073/pnas.220414397
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发表时间：
2000-10-24
影响因子：
11.1
通讯作者：
Penninger, JM
中科院分区：
文献类型：
--
作者：
Oliveira-dos-Santos, AJ;Matsumoto, G;Penninger, JM
G蛋白信号传导调节剂（RCS）蛋白在体外加速G α蛋白亚基的GTP酶活性，负调节G蛋白偶联受体信号传导。哺乳动物RGS蛋白的生理作用在很大程度上是未知的。RGS家族成员rgs 2被克隆为活化后在T淋巴细胞中上调的立即早期应答基因。为了研究RGS 2在体内的作用，我们产生了RGS 2缺陷小鼠。我们发现，小鼠中rgs 2的靶向突变导致T细胞增殖和IL-2产生减少，这在体内转化为抗病毒免疫力受损。很有趣。在没有认知或运动缺陷的情况下，RGS 2（-/-）小鼠也显示出增加的焦虑反应和减少的雄性攻击性。RGS 2还控制海马CA 1神经元的突触发育和基础电活动。因此，RGS 2在T细胞活化、海马中的突触发育和情绪行为中起重要作用。
Regulators of G protein signaling (RCS) proteins accelerate the GTPase activity of G alpha protein subunits in vitro, negatively regulating G protein-coupled receptor signaling. The physiological role of mammalian RGS proteins is largely unknown. The RGS family member rgs2 was cloned as an immediate early response gene up-regulated in T lymphocytes after activation. To investigate the role of RGS2 in vivo, we generated rgs2-deficient mice. We show that targeted mutation of rgs2 in mice leads to reduced T cell proliferation and IL-2 production, which translates in an impaired antiviral immunity in vivo. Interestingly. rgs2(-/-) mice also display increased anxiety responses and decreased male aggression in the absence of cognitive or motor deficits. RGS2 also controls synaptic development and basal electrical activity in hippocampal CA1 neurons. Thus, RGS2 plays an important role in T cell activation, synapse development in the hippocampus, and emotive behaviors.