Desmosome regulation and signaling in disease.
Desmosome regulation and signaling in disease.
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DOI：
10.1007/s00441-015-2136-5
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发表时间：
2015-06
影响因子：
3.6
通讯作者：
Green, Kathleen J.
中科院分区：
文献类型：
--
作者：
Broussard, Joshua A.;Getsios, Spiro;Green, Kathleen J.
桥粒是细胞-细胞粘附性细胞器，在胚胎发生期间和在经受机械应力的成体组织（如心脏和皮肤）中在形成强的细胞间粘附中具有众所周知的作用。最近，桥粒组分也作为细胞信号调节剂出现。桥粒分子的表达缺失或功能干扰导致心脏和皮肤疾病，并有助于癌症进展。然而，导致遗传性和获得性疾病的潜在分子机制仍然知之甚少。为了解决这个问题，研究人员正在将他们的研究导向确定在连接内外发生的功能以及功能依赖或独立的程度。本文综述了最近的发现，提供深入了解桥粒和桥粒组分在细胞信号传导和疾病中的作用，只要有可能，我们解决的粘附结构内外的分子功能。
Desmosomes are cell-cell adhesive organelles with a well-known role in forming strong intercellular adhesion during embryogenesis and in adult tissues subject to mechanical stress, such as the heart and skin. More recently, desmosome components have also emerged as cell signaling regulators. Loss of expression or interference with the function of desmosome molecules results in diseases of the heart and skin and contributes to cancer progression. However, the underlying molecular mechanisms that result in inherited and acquired disorders remain poorly understood. To address this question, researchers are directing their studies towards determining the functions that occur inside and outside of the junctions and the extent to which functions are adhesion-dependent or independent. This review focuses on recent discoveries that provide insights into the role of desmosomes and desmosome components in cell signaling and disease; wherever possible, we address molecular functions within and outside of the adhesive structure.
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