Autoimmune myelofibrosis with pancytopenia as a presenting manifestation of systemic lupus erythematosus responsive to mycophenolate mofetil
Autoimmune myelofibrosis with pancytopenia as a presenting manifestation of systemic lupus erythematosus responsive to mycophenolate mofetil
复制标题
DOI：
10.1177/0961203315615221
复制
发表时间：
2016-04-01
期刊：
影响因子：
2.6
通讯作者：
Makol, A.
中科院分区：
文献类型：
--
作者：
Ungprasert, P.;Chowdhary, V. R.;Makol, A.
血液学异常，如贫血、白细胞减少和血小板减少，继发于外周破坏，在系统性红斑狼疮（SLE）中很常见。然而，自身免疫性骨髓纤维化（AIMF）引起的细胞减少症在SLE中极为罕见，文献中报道的病例不到40例。我们报告一例33岁的女性，她以大疱性皮肤病变和全血细胞减少为主要表现，最终被诊断为SLE伴AIMF。她对糖皮质激素和霉酚酸酯反应良好。
Hematological abnormalities, such as anemia, leucopenia, and thrombocytopenia, secondary to peripheral destruction, are common in systemic lupus erythematosus (SLE). However, cytopenias from autoimmune myelofibrosis (AIMF) are extremely uncommon in SLE, with less than 40 reported cases in the literature. We report the case of a 33-year-old female who presented with bullous skin lesions and pancytopenia as the presenting manifestation of what was ultimately diagnosed as SLE with AIMF. She responded well to glucocorticoids and mycophenolate mofetil.