NECROTIZING MYELOPATHY ASSOCIATED WITH VISCERAL CARCINOMA.
NECROTIZING MYELOPATHY ASSOCIATED WITH VISCERAL CARCINOMA.
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与内脏癌相关的坏死性脊髓病。
DOI：
10.1093/brain/87.4.639
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发表时间：
1964
期刊：
影响因子：
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通讯作者：
R. K. Rosales
中科院分区：
文献类型：
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作者：
E. Mancall;R. K. Rosales
近年来，除了转移性扩散的参与外，几种独特的神经系统疾病已被认为是体内恶性肿瘤的并发症。其中最明确的是亚急性癌性小脑或脊髓小脑变性（Brouwer，1919; Casper，1929;帕克和Kernohan，1933;格林菲尔德，1934; Brain等，1951）和癌性神经病（Auche，1890; Denny-Brown，1948; Wyburn-Mason，1948;伦诺克斯和Pritchard，1950; Henson等，1954; Heathfield和威廉姆斯，1954）;进行性多灶性白质脑病（Astrom等，1958; Richardson，1961），主要发生于淋巴瘤和慢性淋巴性白血病，也可包括在该组中。虽然这些疾病和共存的恶性肿瘤之间的确切关系尚未得到澄清，它通常被认为是一些继发于肿瘤的代谢故障可能是其发生的基础。除了这些相对明确的实体，主要涉及脊髓的退行性过程偶尔被描述为与身体其他部位的肿瘤有关（Nonne，1903年; Nonne，1919年; Feindel，1921年; D 'Antona，1926年; Moersch和Kernohan，1934年; Juba，1938年; Lhermitte和Bussiere de Robert，1941年; Jaffe和Freeman，1943年; Mathieson，1963年）。这种改变与癌性神经病脊髓的继发性改变和与癌性小脑变性相关的系统化的神经束变性不同。所报告的病例通常以进行性上行节段性感觉运动缺陷为特征，发病突然，发展迅速，在几天或几周内死亡。病理学上，片状和非系统化但大致对称的次全和全组织坏死过程，包括
WITHIN recent years several distinctive disorders of the nervous system have been recognized as complications of malignant growths in the body apart from involvement by metastatic spread. The most clearly established of these are subacute carcinomatous cerebellar, or spino-cerebellar, degeneration (Brouwer, 1919; Casper, 1929; Parker and Kernohan, 1933; Greenfield, 1934; Brain et ah, 1951) and carcinomatous neuropathy (Auche, 1890; Denny-Brown, 1948; Wyburn-Mason, 1948; Lennox and Pritchard, 1950; Henson et ah, 1954; Heathfield and Williams, 1954); progressive multifocal leucoencephalopathy (Astrom et ah, 1958; Richardson, 1961), occurring predominantly with lymphoma and chronic lymphatic leukaemia, may also be included in this group. Although the exact relationship between these disorders and the co-existing malignancy has not been clarified, it is often assumed that some metabolic fault secondary to the tumour may underlie their occurrence. In addition to such relatively well-defined entities, a degenerative process primarily involving the spinal cord has occasionally been described in association with neoplasms elsewhere in the body (Nonne, 1903; Nonne, 1919; Feindel, 1921; D'Antona, 1926; Moersch and Kernohan, 1934; Juba, 1938; Lhermitte and Bussiere de Robert, 1941; Jaffe and Freeman, 1943; Mathieson, 1963). The alterations have been distinct from both the secondary changes encountered in the cord in carcinomatous neuropathy and the systematized tract degenerations associated with carcinomatous cerebellar degeneration. The cases so reported have generally been characterized by a progressive ascending segmental sensorimotor deficit, abrupt in onset and rapid in evolution, terminating in death in a matter of days or weeks. Pathologically, a patchy and non-systematized but roughly symmetrical process of subtotal and total tissue necrosis involving