Alkane hydroxylation by a nonheme iron catalyst that challenges the heme paradigm for oxygenase action
Alkane hydroxylation by a nonheme iron catalyst that challenges the heme paradigm for oxygenase action
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DOI：
10.1021/ja077761n
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发表时间：
2007-12-26
影响因子：
15
通讯作者：
Costas, Miquel
中科院分区：
文献类型：
--
作者：
Company, Anna;Gomez, Laura;Costas, Miquel
非血红素铁催化剂催化的立体选择性氧化烷烃与H2 O2具有显着的效率，并表现出前所未有的高纳入水的氧化产物。目前的研究结果挑战加氧酶的规范描述，标准的氧-羟互变异构，适用于血红素系统，并作为一个先例，在非血红素铁加氧酶的碳氢化合物的氧化的替代途径。
A nonheme iron catalyst catalyzed stereoselective oxidation of alkanes with H2O2 with remarkable efficiency and exhibiting an unprecedented high incorporation of water into the oxidized products. The present results challenge the canonical description of oxygenases, the standard oxo-hydroxo tautomerism that applies to heme systems and serves as a precedent for alternative pathways for the oxidation of hydrocarbons at nonheme iron oxygenases.